Proflavine hemisulfate
Proflavine hemisulfate Basic information
- Product Name:
- Proflavine hemisulfate
- Synonyms:
-
- PROFLAVINE HEMISULFATE SALT HYDRATE(RG)
- Proflavine hemisulfate salt dihydrate
- 3,6-acridinediamine,sulfate(2:1)
- 3,6-diamino-acridinsulfate(2:1)
- PROFLAVINE SULFATE
- PROFLAVINE HEMISULFATE
- PROFLAVINE HEMISULFATE SALT
- PROFLAVINE HEMISULPHATE
- CAS:
- 1811-28-5
- MF:
- C13H13N3O4S
- MW:
- 307.32
- EINECS:
- 217-320-3
- Product Categories:
-
- Inhibitors
- Miscellaneous
- Biochemistry
- Vitamin Derivatives
- Vitamins
- Mol File:
- 1811-28-5.mol
Proflavine hemisulfate Chemical Properties
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly, Heated), Water (Slightly, Heated)
- form
- powder
- color
- Orange to Amber to Dark red
- PH
- pH (1g/l, 25℃) : 4.0～8.0
- Water Solubility
- H2O: 10mg/mL
- BRN
- 3921806
- Stability:
- Hygroscopic
- EPA Substance Registry System
- 3,6-Acridinediamine, sulfate (2:1) (1811-28-5)
Proflavine hemisulfate Usage And Synthesis
Description
Proflavine Hemisulfate, the hemisulfate form of proflavin, is an acridine-derived fluorescent contrast agent and disinfectant used for cell imaging and antiseptic purposes. Following topical application, proflavin diffuses into cells and intercalates into DNA, leading to its accumulation in and staining of the nucleus. This allows visualization of the nucleus during fluorescence imaging. Such capability enables nuclear morphometry and facilitates the identification of cancer cells. Additionally, proflavin sulfate exerts antimicrobial effects through binding to bacterial DNA, which disrupts DNA synthesis and inhibits bacterial cell growth.
Chemical Properties
orange to brown crystalline powder
Uses
An Acridine derivative with limited antifungal activity
Uses
Proflavine Hemisulfate is used in preparation of Adenine and Adenine nucleotides via photochemical demethylation of methyladenines.
Purification Methods
An aqueous solution, after treatment with charcoal, is concentrated, chilled overnight, filtered and the precipitate is rinsed with a little diethyl ether. The precipitate is dried in air, then overnight in a vacuum oven at 70o. [Beilstein 22 I 650, 22/11 V 323.]
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Proflavine hemisulfate(1811-28-5)Related Product Information
- 3,6-DIAMINOACRIDINE HYDROCHLORIDE
- CI NO 46040
- ACRIDINE ORANGE
- ACRIDINE ORANGE
- ACRIFLAVINE
- Basic Orange 14
- NONYL ACRIDINE ORANGE
- CI 46025
- PROFLAVINE
- Proflavine hemisulfate
- Acriflavine hydrochloride
- CORIPHOSPHINE O
- 2,8-BIS(DIMETHYLAMINO)-10-DODECYL-ACRIDINIUM BROMIDE
- PROFLAVINE HEMISULFATE,PROFLAVINE HEMISULFATE N-HYDRATE
- BENZOFLAVIN
- 3,6-DIAMINO-10-METHYLACRIDINIUM CHLORIDE
- POLY(PYROMELLITIC DIAHYDRIDE-ALT-PROFLAVINE HEMISULFATE)
- POLY(3,3',4,4'-BENZOPHENONETETRACARBOXYLIC DIANHYDRIDE-ALT-PROFLAVINE HEMISULFATE)