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6-Cyano-2-naphthol

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6-Cyano-2-naphthol Basic information

Product Name:
6-Cyano-2-naphthol
Synonyms:
  • 6-CYANO-2-NAPHTHOL
  • 6-HYDROXY-NAPHTHALENE-2-CARBONITRILE
  • 6-HYDROXY-2-NAPHTHALENECARBONITRILE
  • 6-HYDROXY-2-NAPHTHONITRILE
  • 6-CYANO-2-NAPHTHOL 99%
  • 6-CYANO-2-NAPHTHALENOL
  • CYANO(6-)-2-NAPTHOL
  • 6-Cyano-2-naphthol (Nafamostat mesylate)
CAS:
52927-22-7
MF:
C11H7NO
MW:
169.18
EINECS:
628-663-7
Product Categories:
  • alcohol|cyanide
  • Intermediates
  • Aromatics Compounds
  • Building Blocks for Liquid Crystals
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chalcones, etc. (Building Blocks for Liquid Crystals)
  • Functional Materials
  • Aromatics
  • C10 to C27
  • Cyanides/Nitriles
  • Nitrogen Compounds
Mol File:
52927-22-7.mol
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6-Cyano-2-naphthol Chemical Properties

Melting point:
165.5-170.5 °C (lit.)
Boiling point:
383.1±15.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Ethanol, Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
pka
8.57±0.40(Predicted)
color 
Pale Brown to Brown
CAS DataBase Reference
52927-22-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29269090

MSDS

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6-Cyano-2-naphthol Usage And Synthesis

Chemical Properties

Brown Crystalline Solid. 6-Cyano-b-naphthol [52927-22-7], 6-cyano2-hydroxynaphthalene, 6-hydroxy-2-naphthoic acid nitrile, Mr 169.17, mp 166 – 167℃ This nitrile is used as an intermediate for the production of liquid crystals and monoamino-oxidase-inhibiting naphthalene-2-oxyalkylamines, which are used as antidepressive agents.

Uses

Intermediate of Nafamostat mesilate (N210000).

Uses

Reactant for:

  • Palladium-catalyzed reduction
  • Nickel-catalyzed cross-coupling reactions
  • Palladium-catalyzed Heck reactions

General Description

6-Cyano-2-naphthol (6CN2) is an aromatic alcohol that can be synthesized from 6-bromo-2-naphthol. It is a superphotoacid with the ground state pKa* value of 8.4 and excited state pKavalue of 0.2, respectively. 6CN2 protonates PANI-ES (polyaniline emeraldine salt) to form PANI-EB (emeraldine base), which shows enhanced conductivity. The proton-transfer kinetics and photophysical behavior of 6CN2 have been investigated.

6-Cyano-2-naphthol Preparation Products And Raw materials

Preparation Products

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