THP-PEG8-Tos
THP-PEG8-Tos Basic information
- Product Name:
- THP-PEG8-Tos
- Synonyms:
-
- THP-PEG8-Tos
- 3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-[(tetrahydro-2H-pyran-2-yl)oxy]-, 1-(4-methylbenzenesulfonate)
- Tos-PEG6-THP
- THP-PEG7-Tos
- CAS:
- 669556-37-0
- MF:
- C24H40O10S
- MW:
- 520.63
- Mol File:
- 669556-37-0.mol
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THP-PEG8-Tos Chemical Properties
- solubility
- Soluble in DMSO, DCM, DMF
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THP-PEG8-Tos Usage And Synthesis
Description
THP-PEG7-Tos is a PEG linker with a THP protecting group and a tosyl moiety. The THP is an alcohol protecting group that can be removed under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Uses
THP-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
THP-PEG8-TosSupplier
Jinan elephant international trading co., LTD
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Shanghai Yihe Biological Technology Co., Ltd.
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Alpha Biopharmaceuticals Co., Ltd
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TargetMol Chemicals Inc.
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