THP-SS-alcohol Usage And Synthesis

Description

THP-SS-alcohol is a cleavable linker contains a THP alcohol protecting group and a disulfide bond. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. The THP protecting group can be removed under acidic conditions.

Uses

THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

THP-SS-alcohol(877864-04-5)Related Product Information

• THP-PEG3
• THP-PEG8-Tos
• TETRAHYDROPYRANYLDIETHYLENEGLYCOL
• THP-PEG4
• THP-SS-PEG1-Tos
• 2-(TETRAHYDRO-2H-PYRAN-2-YLOXY)ETHANOL
• THP-SS-PEG1-t-butyl ester