THP-SS-PEG1-Tos Chemical Properties

Boiling point:

539.4±50.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

THP-SS-PEG1-Tos Usage And Synthesis

Description

THP-SS-PEG1-Tos is a cleavable linker containing a THP protecting group and a tosyl end group. Tos is a good leaving group by reacting with nucleophiles, The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent.

Uses

THP-SS-PEG1-Tos is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

THP-SS-PEG1-Tos(1807512-37-3)Related Product Information

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• THP-SS-PEG1-t-butyl ester