5-AMINOVALERIC ACID HYDROCHLORIDE Chemical Properties

Melting point:

95-97 °C(lit.)

Boiling point:

131-132 °C(Press: 3 Torr)

Density 

1.0962 g/cm3

storage temp. 

Store at room temperature

form 

powder to crystal

color 

White to Light yellow to Light orange

Sensitive 

Hygroscopic

BRN 

3683907

Major Application

peptide synthesis

InChI

1S/C5H11NO2.ClH/c6-4-2-1-3-5(7)8;/h1-4,6H2,(H,7,8);1H

InChIKey

BLOIUFYKQCCAGP-UHFFFAOYSA-N

SMILES

Cl[H].NCCCCC(O)=O

CAS DataBase Reference

627-95-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

HS Code 

2922.49.4950

Storage Class

13 - Non Combustible Solids

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

5-AMINOVALERIC ACID HYDROCHLORIDE Usage And Synthesis

Chemical Properties

LIGHT PINK CRYSTALLINE POWDER

Uses

5-Aminovaleric Acid Hydrochloride is used in the synthesis of precursors and fragments of antibiotics XIV and in the study of the reaction of thiolactams with ethyl chloroacatate. Reagent in the preparation of hydroxymethyl dihydroisoxazole derivatives useful as antibiotics agents.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

There are three main biosynthetic pathways for 5-aminopentanoic acid: the enzyme-catalyzed pathway, the whole-cell-catalyzed pathway and the fermentation pathway. The conversion solution of 5-aminopentanoic acid obtained by the enzyme-catalyzed pathway was NH4HCO3 solution at pH 7.8, and the conversion solution also contained a small amount of the substrate lysine and the product 5-aminopentanoic acid; the conversion solution of 5-aminopentanoic acid obtained by whole-cell-catalyzed method contained about 14 g/L phosphate buffer solution, about 2 g/L sulfate, and a small amount of lysine and glucose; the conversion solution of 5-aminopentanoic acid obtained by fermentation method contained about 10 g/L phosphate, about 2 g/L sulfate, and about 2 g/L glucose. The fermentation broth of 5-aminopentanoic acid obtained by the fermentation method contained about 10 g/L of phosphate, about 16 g/L of sulfate, and a small amount of remaining glucose and lysine; the 5-aminopentanoic acid was separated by an ion exchange resin using a method for separating ??-aminobutyric acid, which was subjected to flocculation and filtration for removing bacterial organisms, and a large-pore adsorption resin for decoloration, and finally the 5-aminopentanoic acid was separated by an ion exchange resin.

Purification Methods

Crystallise the salt from CHCl3. Otherwise dissolve it in EtOH and add 2 volumes of Et2O and chill. [Schniepp & Marvel J Am Chem Soc 57 1557 1935, Woods & Colver J Am Chem Soc 67 654 1945, Beilstein 4 III 1343, 4 IV 2636.]

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• 5-AMINOVALERIC ACID HYDROCHLORIDE = 5-AMINOPENTANOIC ACID HYDROCHLORIDE