Oxiconazole Chemical Properties

Boiling point:

576.8±60.0 °C(Predicted)

Density 

1.42±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

6.14±0.12(Predicted)

CAS DataBase Reference

64211-45-6(CAS DataBase Reference)

Oxiconazole Usage And Synthesis

Description

Oxiconazole is a substituted imidazole derivative,it is structurally distinct from miconazole, econazole, clotrimazole, and ketoconazole because it is an acetophene-oxime derivative. It has a broad spectrum of antifungal activity including activity against yeasts, dermatophytes, and Aspergillus species.

Uses

Antifungal.
Oxiconazole (Oxistat) is a synthetic imidazole that works, in part, by inhibiting ergosterol 2,3-epoxidase synthesis and thereby disrupting cell membrane integrity.

Uses

Oxiconazole is used as an antifungal agent.

Indications

Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, oxiconazole is indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.

Definition

ChEBI: An oxime O-ether that is the 2,4-dichlorobenzyl ether of the oxime obtained by formal condensation of hydroxylamine with the carbonyl group of acetopnenone in which the phenyl group is substituted by chlorines at positions 2 and 4, and i which one of the hydrogens of the methyl group is replaced by a 1H-imidazol-1-yl group. An antifungal agent, it is used (generally as the nitrate salt) in creams and powders for the topical treatment of fungal skin infections.

brand name

Oxistat (Altana).

Antimicrobial activity

Broad-specktrum imidazole antimycotic with activity against almost all species of pathogenic fungi.

Side effects

Local irritations such as itching and burning sensations, and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.

Oxiconazole(64211-45-6)Related Product Information

• 3-Nitroacetophenone
• 3-Aminoacetophenone
• PIPERACETAZINE (250 MG)
• 4'-Hydroxyacetophenone
• Itraconazole
• Miconazole
• 2-Bromoacetophenone
• 2'-Hydroxyacetophenone
• 4'-Bromoacetophenone
• Acetophenone
• 2',4'-Dichloroacetophenone
• Fluconazole
• Ketoconazole
• 4-Nitroacetophenone
• Miconazole nitrate
• Dichloroacetonitrile
• Oxiconazole nitrate
• 2,4'-Dichloroacetophenone