2-[2-(2-Propyn-1-yloxy)ethoxy]acetic acid Chemical Properties

Boiling point:

294.2±20.0 °C(Predicted)

Density 

1.169±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

pka

3.37±0.10(Predicted)

color 

Colorless to light yellow

2-[2-(2-Propyn-1-yloxy)ethoxy]acetic acid Usage And Synthesis

Uses

Propynyl-PEG1-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propynyl-PEG1-Ac is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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