t-Boc-N-Amido-PEG2-Propargyl Chemical Properties

Boiling point:

344.2±27.0 °C(Predicted)

Density 

1.033±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

pka

12.22±0.46(Predicted)

color 

Colorless to light yellow

t-Boc-N-Amido-PEG2-Propargyl Usage And Synthesis

Description

t-Boc-N-Amido-PEG2-propargyl is crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-Boc protected amine can be deprotected under mild acidic conditions.

Uses

Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Cleavable Linker; PEGs; Alkyl/ether

References

[1] Nello Mainolfi, et al. rak degraders and uses thereof. US20190192668A1.

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