4-IODOTETRAHYDRO-2H-PYRAN Chemical Properties

Boiling point:

79 °C

Density 

1.77±0.1 g/cm3(Predicted)

refractive index 

1.5471

storage temp. 

2-8°C(protect from light)

form 

liquid

color 

Clear, colourless

InChI

InChI=1S/C5H9IO/c6-5-1-3-7-4-2-5/h5H,1-4H2

InChIKey

JTRNQTFTRDPITG-UHFFFAOYSA-N

SMILES

C1OCCC(I)C1

Safety Information

Hazard Codes 

Xi

Risk Statements 

36-36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

29329990

4-IODOTETRAHYDRO-2H-PYRAN Usage And Synthesis

Synthesis

GENERAL STEPS: Tetrahydro-2H-pyran-4-ol (2.0 g, 19.58 mmol), imidazole (1.600 g, 23.50 mmol), triphenylphosphine (5.39 g, 20.56 mmol) and tetrahydrofuran (39.2 mL) were added to a round bottom flask (RBF) and the mixture was cooled to 0 °C. A solution of iodine (5.96 g, 23.50 mmol) in tetrahydrofuran (39.2 mL) was slowly added dropwise with stirring. After dropwise addition, the reaction mixture was gradually warmed to room temperature and stirring was continued overnight. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed with deionized water. The aqueous layer was back-extracted with ethyl acetate, all organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification of the crude product by column chromatography (using a RediSep Gold 80g silica gel column eluting with a 0-50% ethyl acetate/heptane gradient) afforded 4-iodotetrahydro-2H-pyran (2.67 g, 12.59 mmol, 64.3% yield) as a clarified light yellow oil.

References

[1] Journal of the American Chemical Society, 2017, vol. 139, # 24, p. 8110 - 8113
[2] Patent: US9212182, 2015, B2. Location in patent: Page/Page column 79
[3] Organic Letters, 2013, vol. 15, # 7, p. 1658 - 1661
[4] Patent: WO2018/106636, 2018, A1. Location in patent: Paragraph 00281
[5] Journal of the Chemical Society, 1952, p. 910,913

4-IODOTETRAHYDRO-2H-PYRAN(25637-18-7)Related Product Information

• Tetrahydrofurfuryl alcohol
• Pro-xylane
• TETRAHYDRO-2H-PYRAN-3-OL
• (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
• 3,4-Dihydro-2H-pyran
• TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE
• Tetrahydro-2H-pyran-4-carboxylic acid
• 4-Aminotetrahydropyran
• Tetrahydro-4H-pyran-4-one
• 3,6-dihydro-2H-pyran
• Methyl tetrahydropyran-4-carboxylate
• 2-methyloxan-4-one
• Tetrahydro-4-pyranol
• 4-BROMOMETHYLTETRAHYDROPYRAN
• 4-BROMO-TETRAHYDROPYRAN
• 4-IODOTETRAHYDRO-2H-PYRAN