4-IODOTETRAHYDRO-2H-PYRAN
- Product Name
- 4-IODOTETRAHYDRO-2H-PYRAN
- CAS No.
- 25637-18-7
- Chemical Name
- 4-IODOTETRAHYDRO-2H-PYRAN
- Synonyms
- 4-iodooxane;4-IODO-TETRAHYDRO-PYRAN;4-IODOTETRAHYDRO-2H-PYRAN;Tetrahydro-4-iodo-2H-pyran;4-Iodotetrahydro-2H-pyrane;2H-Pyran, tetrahydro-4-iodo-;4-Iodotetrahydro-2H-pyran 97%;25637-184-IODOTETRAHYDRO-2H-PYRAN-7;4-Iodotetrahydro-2H-pyran,97%,stabilized with Na2O3S2
- CBNumber
- CB6403559
- Molecular Formula
- C5H9IO
- Formula Weight
- 212.03
- MOL File
- 25637-18-7.mol
4-IODOTETRAHYDRO-2H-PYRAN Property
- Boiling point:
- 79 °C
- Density
- 1.77±0.1 g/cm3(Predicted)
- refractive index
- 1.5471
- storage temp.
- 2-8°C(protect from light)
- form
- liquid
- color
- Clear, colourless
- InChI
- InChI=1S/C5H9IO/c6-5-1-3-7-4-2-5/h5H,1-4H2
- InChIKey
- JTRNQTFTRDPITG-UHFFFAOYSA-N
- SMILES
- C1OCCC(I)C1
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36-36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I720423
- Product name
- 4-Iodotetrahydro-2H-pyran
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 280843
- Product name
- 4-Iodotetrahydro-2H-pyran
- Packaging
- 250mg
- Price
- $372
- Updated
- 2021/12/16
- Product number
- OR9693
- Product name
- 4-Iodotetrahydro-2H-pyran
- Purity
- 97%
- Packaging
- 1g
- Price
- $34
- Updated
- 2021/12/16
- Product number
- 2H10-H-X0
- Product name
- 4-Iodotetrahydro-2H-pyran
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-W004278
- Product name
- 4-Iodotetrahydro-2H-pyran
- Purity
- 99.68%
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
4-IODOTETRAHYDRO-2H-PYRAN Chemical Properties,Usage,Production
Synthesis
2081-44-9
25637-18-7
GENERAL STEPS: Tetrahydro-2H-pyran-4-ol (2.0 g, 19.58 mmol), imidazole (1.600 g, 23.50 mmol), triphenylphosphine (5.39 g, 20.56 mmol) and tetrahydrofuran (39.2 mL) were added to a round bottom flask (RBF) and the mixture was cooled to 0 °C. A solution of iodine (5.96 g, 23.50 mmol) in tetrahydrofuran (39.2 mL) was slowly added dropwise with stirring. After dropwise addition, the reaction mixture was gradually warmed to room temperature and stirring was continued overnight. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed with deionized water. The aqueous layer was back-extracted with ethyl acetate, all organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification of the crude product by column chromatography (using a RediSep Gold 80g silica gel column eluting with a 0-50% ethyl acetate/heptane gradient) afforded 4-iodotetrahydro-2H-pyran (2.67 g, 12.59 mmol, 64.3% yield) as a clarified light yellow oil.
References
[1] Journal of the American Chemical Society, 2017, vol. 139, # 24, p. 8110 - 8113
[2] Patent: US9212182, 2015, B2. Location in patent: Page/Page column 79
[3] Organic Letters, 2013, vol. 15, # 7, p. 1658 - 1661
[4] Patent: WO2018/106636, 2018, A1. Location in patent: Paragraph 00281
[5] Journal of the Chemical Society, 1952, p. 910,913
4-IODOTETRAHYDRO-2H-PYRAN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-IODOTETRAHYDRO-2H-PYRAN manufacturers
- Product
- 4-iodotetrahydro-2H-pyran 25637-18-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22
- Product
- 4-IODOTETRAHYDRO-2H-PYRAN 25637-18-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
- Product
- 4-Iodotetrahydro-2H-pyran 25637-18-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2018-08-16