ETHYLTHIOUREA Chemical Properties

Melting point:

108-110 °C(lit.)

Boiling point:

132 °C

Density 

1.055 (estimate)

refractive index 

1.5500 (estimate)

storage temp. 

Store at RT

solubility 

methanol: soluble25mg/mL, clear, colorless

form 

Solid

pka

14.97±0.29(Predicted)

color 

White to Off-White

Water Solubility 

Soluble in water (24g/L).

BRN 

1699551

InChIKey

GMEHFXXZSWDEDB-UHFFFAOYSA-N

CAS DataBase Reference

625-53-6(CAS DataBase Reference)

EPA Substance Registry System

Ethylthiourea (625-53-6)

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

36/37/39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

YT3700000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

Hazardous Substances Data

625-53-6(Hazardous Substances Data)

Toxicity

mouse,LDLo,oral,500mg/kg (500mg/kg),Teratology, The International Journal of Abnormal Development. Vol. 23, Pg. 335, 1981.

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

ETHYLTHIOUREA Usage And Synthesis

Uses

N-Ethylthiourea was used in the preparation of Re (III) complexes, which are precursors for the new rhenium complexes, potentially useful in nuclear medicine. It was also used in two-step protocol for the first chemoselective cleavage of 2-hydroxy acid amides

Definition

ChEBI: N-ethylthiourea is a member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by an ethyl group. It is functionally related to a thiourea.

General Description

N-Ethylthiourea forms adduct with silver halides and their single crystal X-ray structural and spectroscopic characterizations are described.

Biological Activity

Potent, selective and reversible inhibitor of isoform II NO synthase (IC 50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).

Safety Profile

Poison by ingestion. SYN: 1-ETHYLTHIOUREA Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Sox and NOx.

Purification Methods

Crystallise the thiourea from EtOH, MeOH or ether. [Beilstein 4 IV 374.]

ETHYLTHIOUREA(625-53-6)Related Product Information

• 2-Thiouracil
• DITHIOURACIL
• Allylthiourea
• ETHYLTHIOUREA
• 2-THIOCYTIDINE
• Methylthiouracil
• Propylthiouracil
• 2-Thiohydantoin
• 6-AZA-2-THIOTHYMINE
• N,N'-Diethylthiourea
• N-ACETYLTHIOUREA
• 4-METHYL-5-(TRIFLUOROMETHYL)-1,2,4-TRIAZOLIN-3(2H)-THIONE
• 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)THIOUREA
• 1-ALLYL-3-(2-HYDROXYETHYL)-2-THIOUREA
• 1,3-Dibutyl-2-thiourea
• 5-(N'-[2-AMINOETHYL]THIOUREIDOFLUORESCEIN)
• 2-(2-PYRIDYL)ETHYLTHIOUREA
• 2-PHENYLETHYLTHIOUREA