H-Lys(Boc)-OH Chemical Properties

Melting point:

250 °C (dec.)(lit.)

alpha 

17 º (c=1% in acetic acid)

Boiling point:

389.3°C (rough estimate)

Density 

1.1313 (rough estimate)

refractive index 

18 ° (C=1, AcOH)

storage temp. 

2-8°C

solubility 

Soluble in DMSO

form 

powder to crystal

pka

2.53±0.24(Predicted)

color 

White to Almost white

optical activity

[α]20/D +18°, c = 1 in acetic acid

Water Solubility 

Slightly soluble in water.

BRN 

2417626

InChIKey

VVQIIIAZJXTLRE-QMMMGPOBSA-N

CAS DataBase Reference

2418-95-3(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29241990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

H-Lys(Boc)-OH Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

It is used as therapy to treat recurrent herpes simplex infections.

General Description

H-Lys(Boc)-OH, also known as H-Lys(t-BOC)-OH, is an ε-amino-protected lysine. Its e-amino free lysine could be conjugated to polyurethane surfaces by reaction of the alpha-amino group with the NHS and deprotection. The covalent conjugation was carried out in phosphate-buffered saline (PBS), pH 8.2. Lysine was used to create a plasminogen-binding potentially fibrinolytic surface[1].

References

[1] Chen H , et al. Surfaces having dual fibrinolytic and protein resistant properties by immobilization of lysine on polyurethane through a PEG spacer. Journal of Biomedical Materials Research Part A, 2008; 90A: 940-946.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Step 1. N-alpha-Fluorenylmethoxycarbonyl-N-epsilon-tert-butoxycarbonyl-L-lysine (5 g, 10.7 mmol) was dissolved in dichloromethane (DCM) at room temperature and piperidine (5.5 ml, 53 mmol) was added with stirring. The reaction mixture was stirred continuously for 16 hours at room temperature. Upon completion of the reaction, the reaction mixture was extracted with water, the aqueous phase was combined and concentrated to afford N(e)-Boc-L-lysine (20-3) in 95% yield.

H-Lys(Boc)-OH(2418-95-3)Related Product Information

• N-Carbobenzyloxyglycine
• Boc-Aib-OH
• Fmoc-N'-methyltrityl-L-lysine
• L-Lysine
• tert-Butyl carbazate
• Poly(L-lysine hydrobromide)
• Poly-L-lysine
• 5-Hydroxytryptophan
• (S)-2-amino-3-(4-(2-tert-butoxy-2-oxoethyl)phenyl)propanoic acid
• H-LYS(ALLOC)-OH
• N-EPSILON-ACETYL-L-LYSINE
• H-Lys(Boc)-OBzl·HCl
• Biocytin
• H-L-Pen-OH.HCl.H2O
• BOC-GLY-LEU-OH
• L-Phenylalanine, 4-cyclohexyl-
• H-L-Lys-NEt2.2HCl
• H-L-Tyr-NEt2.HCl