VU0453379 Chemical Properties

Boiling point:

671.8±55.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

13.46±0.20(Predicted)

color 

Off-white to light yellow

Water Solubility 

H2O: 20mg/mL, clear

VU0453379 Usage And Synthesis

Biological Activity

VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC50 = 1.3 μ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson′s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg.

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