5,6,7,8-Tetrahydroquinoline Chemical Properties

Boiling point:

238°C

Density 

1,08 g/cm³

refractive index 

1.5420 to 1.5450

Flash point:

90°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Sparingly) Methanol (Slightly)

form 

Oil

pka

6.30±0.20(Predicted)

color 

Colourless

Specific Gravity

1.0341.0304 (20/4℃)

InChI

InChI=1S/C9H11N/c1-2-6-9-8(4-1)5-3-7-10-9/h3,5,7H,1-2,4,6H2

InChIKey

YQDGQEKUTLYWJU-UHFFFAOYSA-N

SMILES

N1C2=C(CCCC2)C=CC=1

CAS DataBase Reference

10500-57-9(CAS DataBase Reference)

NIST Chemistry Reference

Quinoline, 5,6,7,8-tetrahydro-(10500-57-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36/37/39-37/39

HS Code 

29334900

5,6,7,8-Tetrahydroquinoline Usage And Synthesis

Chemical Properties

Colorless to light yellow liquid

Uses

5,6,7,8-Tetrahydroquinoline can be used to prevent and treat of hyperlipemia.

Synthesis

5,6,7,8-Tetrahydroquinoline is prepared by the reaction of pyridine and 1,4-dichlorobutane. The specific synthesis steps are as follows:
At 25℃ and an inert atmosphere,Compound 2 (2.67 g, 21.02 mmol) was added to a suspension of aluminum chloride (0.20 g, 1.5 mmol) in pyridine (10 mL). After stirring the obtained orange solution for 24 hours, It was poured into an ice water mixture (50 g) and extracted with ethyl acetate (50 mL).The organic layer was separated and washed sequentially with water (50 mL). The organic layer was washed with saturated sodium bicarbonate solution (50 mL) and brine (50 mL). It was then dried over NaSO4 and concentrated in vacuo. The yellow oil was subjected to flash chromatography on silica gel (eluent: hexane), Obtaining 5,6,7,8-tetrahydroquinoline, 2.66 g, yield 95%.

5,6,7,8-Tetrahydroquinoline (10500-57-9)Related Product Information

• Isoquinoline
• Ethoxyquin
• 3-Hydroxypyridine
• 8-Hydroxyquinoline
• Pyridine
• 3-Aminopyridine
• Quinhydrone
• Quinclorac
• Quinolinic acid
• 2-Chloro-3-hydroxypyridine
• QUINOLINE SULPHATE
• Quinoline Yellow
• Chromium picolinate
• Cyclohexanone
• 1,2,3,4-TETRAHYDRO-9-ACRIDINECARBOXYLIC ACID DIHYDRATE
• 5,6,7,8-tetrahydro-3-methylquinoline
• 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
• 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE