tert-Butyl carbamate Chemical Properties

Melting point:

105-108 °C (lit.)

Boiling point:

218.95°C (rough estimate)

Density 

1.1274 (rough estimate)

refractive index 

1.4206 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

13.59±0.50(Predicted)

form 

Needles

color 

White to slightly yellow

Water Solubility 

Soluble in methylene chloride, chloroform, and alcohols. Slightly soluble in petroleum ether and water.

BRN 

1744500

CAS DataBase Reference

4248-19-5(CAS DataBase Reference)

NIST Chemistry Reference

Tert-butyl carbamate(4248-19-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

39-26-24/25

WGK Germany 

3

HS Code 

29241990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

tert-Butyl carbamate Usage And Synthesis

Chemical Properties

White to slightly yellow needles

Uses

tert-Butyl carbamate was used in palladium-catalyzed synthesis of N-Boc-protected anilines. It was used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 3421, 1963 DOI: 10.1021/jo01047a033

General Description

Palladium-catalyzed cross-coupling reaction of tert-butyl carbamate with various aryl(Het) halides with Cs₂CO₃ as base in 1,4-dioxane (solvent) has been investigated.

tert-Butyl carbamate(4248-19-5)Related Product Information

• Urethane
• tert-Butyl 4-aminobenzoate
• Rink Amide Linker
• tert-Butyl peroxybenzoate
• tert-Butyl glycinate
• Dibutyl phthalate
• tert-Butyl carbazate
• Chlorpropham
• RINK AMIDE RESIN
• Diethylene glycol monobutyl ether
• BUTYL OLEATE
• Butyl formate
• n-Butyl carbamate
• Butyl acetate
• tert-Butyl acetate
• POLYURETHANE
• Fomesafen
• 4-Aminobenzoic acid