Tibulizumab CAS#: 1849636-24-3

Tibulizumab Basic information

Product Name:

Tibulizumab

Synonyms:

Tibulizumab
Research Grade Tibulizumab

CAS:

1849636-24-3

MW:

0

Mol File:

Mol File

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Tibulizumab Usage And Synthesis

Uses

Tibulizumab (LY 3090106) is a tetravalent bispecific monoclonal antibody targeting B-cell activating factor (BAFF) and IL-17A with Kd values of 60 pM and 14 pM, respectively. Tibulizumab can be used for autoimmune disease research[1].

in vivo

Tibulizumab (LY 3090106; 660 μg/mouse, i.p; 66 μg/mouse, s.c) effectively antagonizes the biological effects induced by human BAFF and IL-17 in the mouse^[1].
In cynomolgus monkey, Tibulizumab (i.v, 0.3, 1, 5, or 20 mg/kg; or s.c, 5 mg/kg) suppresses B cell development and survival and remains functionally intact in circulation, with a prolonged half-life^[1].

IC 50

IL-17A: 14 pM (Kd); BAFF: 60 pM (Kd)

References

[1] Robert J Benschop, et al. Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease. MAbs. 2019 Aug/Sep;11(6):1175-1190. DOI:10.1080/19420862.2019.1624463

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