Modotuximab Chemical Properties

form 

Liquid

color 

Colorless to light yellow

Modotuximab Usage And Synthesis

Uses

Modotuximab (DS 1024) is an IgG1κ-type chimeric antibody targeting human EGFR protein. Modotuximab binds non-overlapping epitopes on domain III of EGFR, a domain that is intact in EGFRvIII. Modotuximab has antitumor activity in vivo[1].

References

[1] Keir ST, et al. Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models. J Neurooncol. 2018 Jul;138(3):489-498. DOI:10.1007/s11060-018-2832-6
[2] Modotuximab. IMGT Database.

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