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cephaeline

Basic information Safety Supplier Related

cephaeline Basic information

Product Name:
cephaeline
Synonyms:
  • cephaeline
  • O-Phosphatidyl-ethanolamine
  • Cefalin
  • (-)-Cephaelin
  • (1R)-1-[[(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-6-isoquinolinol
  • 7',10,11-Trimethoxyemetan-6'-ol
  • Cepheline
  • Desmethylemetine
CAS:
483-17-0
MF:
C28H38N2O4
MW:
466.61
EINECS:
207-591-6
Product Categories:
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
483-17-0.mol
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cephaeline Chemical Properties

Melting point:
115-1160C
alpha 
D20 -43.4° (c = 2 in chloroform)
Boiling point:
569.42°C (rough estimate)
Density 
1.21±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5800 (estimate)
storage temp. 
-20°C Freezer
solubility 
Acetonitrile: slightly soluble; Chloroform: slightly soluble; Ethanol: slightly soluble; Methanol: slightly soluble
form 
A crystalline solid
pka
9.90±0.40(Predicted)
color 
Light yellow to yellow
Stability:
Hygroscopic
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Safety Information

RIDADR 
1544
HazardClass 
6.1(b)
PackingGroup 
III
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cephaeline Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

Has been used as an emetic and expectorant

Uses

Cephaeline occurs in the ground roots ofipecac along with emetine. The Brazilian variety usually contains about 0.5%cephaeline. It is used as an emetic and anti amebic reagent.

Definition

ChEBI: A pyridoisoquinoline comprising emetam having a hydroxy group at the 6'-position and methoxy substituents at the 7'-, 10- and 11-positions.

Health Hazard

The toxicity of cephaeline is lower than thatof emetine. The toxic effects are cumula tive. Ingestion of high doses may producehypotension, muscle weakness, and gastroin testinal problems, including nausea, vomiting, and diarrhea.

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