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O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine

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O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Basic information

Product Name:
O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
Synonyms:
  • O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
  • 3,5-Diiodo-L-tyrosinedihydrae
  • (S)-α-Amino-4-[(4-hydroxy-3-iodophenyl)oxy]-3-iodobenzenepropanoic acid
  • 3-Iodo-O-(4-hydroxy-3-iodophenyl)-L-tyrosine
  • O-(3-Iodo-4-hydroxyphenyl)-3-iodo-L-tyrosine
  • 3,3'-Diiodo-L-thyronine
  • (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid
  • (2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo-phenyl]propionic acid
CAS:
4604-41-5
MF:
C15H13I2NO4
MW:
525.08
EINECS:
225-005-7
Product Categories:
  • Amino Acids & Derivatives
  • Labeling and Diagnostics Reagents
Mol File:
4604-41-5.mol
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O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Chemical Properties

Melting point:
178-180°C
Boiling point:
520.7±50.0 °C(Predicted)
Density 
2.095±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Aqueous Base (Slightly)
form 
Solid
pka
2.17±0.20(Predicted)
color 
Off-White to Beige
Stability:
Light Sensitive
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Safety Information

WGK Germany 
3
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O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Usage And Synthesis

Description

3,3''-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3’-T2. It is derived enzymatically from triiodothyronine isoforms T3 and reverse T3. T2 and its analog 3,5-T2 stimulate the activity of cytochrome c oxidase by blocking inhibition by ATP.

Chemical Properties

Off-White Powder

Uses

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

Definition

ChEBI: 3,3'-diiodo-L-thyronine is a 3,3'-diiodothyronine. It has a role as a human metabolite.

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