O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Chemical Properties

Melting point:

178-180°C

Boiling point:

520.7±50.0 °C(Predicted)

Density 

2.095±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

Aqueous Base (Slightly)

form 

Solid

pka

2.17±0.20(Predicted)

color 

Off-White to Beige

Stability:

Light Sensitive

InChI

InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)/t12-/m0/s1

InChIKey

CPCJBZABTUOGNM-LBPRGKRZSA-N

SMILES

C(O)(=O)[C@H](CC1=CC=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)N

Safety Information

WGK Germany 

3

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Usage And Synthesis

Description

3,3''-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3’-T2. It is derived enzymatically from triiodothyronine isoforms T3 and reverse T3. T2 and its analog 3,5-T2 stimulate the activity of cytochrome c oxidase by blocking inhibition by ATP.

Chemical Properties

Off-White Powder

Uses

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

Definition

ChEBI: 3,3'-diiodo-L-thyronine is a 3,3'-diiodothyronine. It has a role as a human metabolite.

IC 50

Human Endogenous Metabolite; COX

References

[1] G PINNA. 3,3’-Diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress.[J]. Journal of Clinical Endocrinology & Metabolism, 1998, 83 9: 3071-3077. DOI: 10.1210/jcem.83.9.5080
[2] F. GOGLIA . Interaction of diiodothyronines with isolated cytochromec oxidase[J]. FEBS Letters, 1994, 346 2: Pages 295-298. DOI: 10.1016/0014-5793(94)00476-5
[3] S ARNOLD  B K  F Goglia. 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP.[J]. European journal of biochemistry, 1998, 252 2: 325-330. DOI: 10.1046/j.1432-1327.1998.2520325.x

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine(4604-41-5)Related Product Information

• REVERSE T3
• 3,5-Diiodo-L-thyronine
• Levothyroxine EP Impurity B
• 4-(4-Hydroxyphenoxy)-3,5-diiodo-benzaldehyde
• 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID
• Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED
• Levothyroxine Impurity 16
• N-ForMyl Thyroxine
• 3,5,3',5'-Tetraiodo Thyroaldehyde
• 3,5-Diiodo-4-(p-Methoxyphenoxy)-benzaldehyde
• 3-IODO-L-TYROSINE
• 3,3',5-TRIIODOTHYROACETIC ACID
• Liothyronine IMpurity E
• Levothyroxine impurity E
• 3,3',5-TRIIODOTHYROPROPIONIC ACID
• Levothyroxine Impurity 14
• Levothyroxine
• Levothyroxine O-Methyl Amine Impurity