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(S)-(-)-5-FLUOROWILLARDIINE

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(S)-(-)-5-FLUOROWILLARDIINE Basic information

Product Name:
(S)-(-)-5-FLUOROWILLARDIINE
Synonyms:
  • 5-fluorowillardiine
  • (S)-(-)-5-FLUOROWILLARDIINE
  • (S)-(-)-ALPHA-AMINO-5-FLUORO-3,4-DIHYDRO-2,4-DIOXO-1(2H)PYRIDINEPROPANOIC ACID
  • (S)-2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid
  • WILLARDIINE, S(-)-5-FLUORO POTENT AMPA/K AINATE A
  • (S)-(-)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid
  • (S)-(-)-α-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)pyridinepropanoicacid
  • (αS)-α-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
CAS:
140187-23-1
MF:
C7H8FN3O4
MW:
217.15
Product Categories:
  • Glutamate receptor
  • Glutamate
Mol File:
140187-23-1.mol
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(S)-(-)-5-FLUOROWILLARDIINE Chemical Properties

Melting point:
>209°C (dec.)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Aqueous Acid (Slightly)
form 
Solid
color 
White to Pale Beige
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(S)-(-)-5-FLUOROWILLARDIINE Usage And Synthesis

Uses

(S)-(-)-5-Fluorowillardiine is a potent and selective AMPA receptor agonist at hGluR1 and hGluR2 (1,2).

Definition

ChEBI: An alanine derivative that is L-alanine bearing a 5-fluorouracil-1-yl substituent at position 3. A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively).

Biological Activity

A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (K i = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively). Also available as part of the AMPA Receptor Tocriset™ .

(S)-(-)-5-FLUOROWILLARDIINESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Ascent Scientific
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4401179829988
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customerservice@ascentscientific.co.uk
MedChemexpress LLC
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021-58955995
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ShangHai KenEn Chemical Technology Co., Ltd.
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13120367189
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mychess007@163.com
EMMX Biotechnology LLC
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888-539-0666
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