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Rutundic acid

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Rutundic acid Basic information

Product Name:
Rutundic acid
Synonyms:
  • 3β,19,23-Trihydroxyurs-12-en-28-oic acid
  • 3β,19α,23-Trihydroxyurs-12-ene-28-oic acid
  • Rotundic acid
  • Rutundic acid
  • (3beta,4alpha)-3,19,23-Trihydroxyurs-12-en-28-oic acid
  • (1R,2R,4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-1,10-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
  • Ilexolic acid A
  • I1exo1ic acid
CAS:
20137-37-5
MF:
C30H48O5
MW:
488.7
Mol File:
20137-37-5.mol
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Rutundic acid Chemical Properties

Melting point:
272-274℃
Boiling point:
622.8±55.0 °C(Predicted)
Density 
1.19
storage temp. 
4°C, protect from light
solubility 
Soluble in DMSO and methanol;
form 
powder
pka
4.47±0.70(Predicted)
color 
White
Water Solubility 
insoluble in water
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Rutundic acid Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Ilex pubescens.

Uses

Rotundic acid, a triterpenoid obtained from Ilex rotunda Thunb., induces DNA damage and cell apoptosis in hepatocellular carcinoma through AKT/mTOR and MAPK Pathways. Rotundic acid possesses anti-inflammatory and cardio-protective abilities[1].

Definition

ChEBI: A natural product found in Euscaphis japonica.

IC 50

mTOR; p38 MAPK

References

[1] Roy G, et al. Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways. Front Oncol. 2019 Jun 26;9:545. DOI:10.3389/fonc.2019.00545

Rutundic acidSupplier

BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Email
y.liu@mail.biobiopha.com
Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
Email
cwb1@biopurify.cn
Shanghai Winherb Medical Technology Co., Ltd.
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021-38218169 13341702378
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winherb@126.com
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Email
tauto@tautobiotech.com
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Email
marketing@targetmol.com
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