Methylnissolin Chemical Properties

Boiling point:

428.9±45.0 °C(Predicted)

Density 

1.312

storage temp. 

4°C, protect from light

solubility 

Acetone: soluble; Chloroform: soluble; Dichloromethane: soluble; DMSO: soluble; Ethyl Acetate: soluble

form 

A solid

pka

9.44±0.20(Predicted)

color 

White to off-white

Methylnissolin Usage And Synthesis

Chemical Properties

It is a white crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from Astragalus membranaceus (Fisch.) Bunge.

Uses

Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].

Definition

ChEBI: Astrapterocarpan is a member of pterocarpans.

IC 50

PDGFR: 10 μM (IC₅₀); ERK1; ERK2

References

[1] Ohkawara S, et al. Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. Eur J Pharmacol. 2005 Nov 21;525(1-3):41-7. DOI:10.1016/j.ejphar.2005.08.063

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