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Trimethyl orthobutyrate

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Trimethyl orthobutyrate Basic information

Product Name:
Trimethyl orthobutyrate
Synonyms:
  • Butane, 1,1,1-trimethoxy-
  • ORTHO-N-BUTYRIC ACID TRIMETHYL ESTER
  • ORTHOBUTYRIC ACID TRIMETHYL ESTER
  • TRIMETHYL ORTHOBUTYRATE
  • 1,1,1-TRIMETHOXYBUTANE
  • Trimethyl orthobutylate
  • RimethylOrthobutyrate
  • o-Trimethyl butyrate
CAS:
43083-12-1
MF:
C7H16O3
MW:
148.2
EINECS:
256-079-9
Product Categories:
  • Organic synthesis
  • Intermediates of Dyes and Pigments
  • Orthoesters
Mol File:
43083-12-1.mol
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Trimethyl orthobutyrate Chemical Properties

Boiling point:
145-147 °C (lit.)
Density 
0.926 g/mL at 25 °C (lit.)
refractive index 
1.402-1.404
Flash point:
50 °C
storage temp. 
Flammables area
solubility 
Chloroform, Ethyl Acetate
form 
Liquid
color 
Clear colorless to slightly yellow
Specific Gravity
0.926
BRN 
1737319
CAS DataBase Reference
43083-12-1(CAS DataBase Reference)
NIST Chemistry Reference
Trimethyl orthobutyrate(43083-12-1)
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Safety Information

Hazard Codes 
Xi,F
Risk Statements 
36/38-10-36/37/38
Safety Statements 
37/39-26-16-36
RIDADR 
UN 3272
WGK Germany 
3
HazardClass 
3.2
PackingGroup 
III
HS Code 
29159000

MSDS

  • Language:English Provider:ACROS
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Trimethyl orthobutyrate Usage And Synthesis

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

Trimethyl orthobutyrate has been used in the preparation of:

  • 5-acetamido-9-O-butyroyl-3,5-dideoxy-D-glycero-2-nonulo pyranosonic acid
  • 9-O-butyroyl-3,5-dideoxy-5-glycoloylamido-D-glycero-2-nonulo pyranosonic acid

Uses

Trimethyl orthobutyrate can be used for:

  • Acylation at OH-9 of N-acetylneuraminic acid and N-glycoloylneuraminic acid to give the corresponding 9-O-acylated derivatives.
  • Conversion of 2-amino-N-(1-H-benzimidazol-2-yl)benzamide to 2-propyl-3-benzimidazolyl-4(3H)-quinazolinone.
  • Preparation of 2-propyl substituted benzimidazoles from 1,2-benzenediamines.

It can also be used in the total synthesis of dl-camptothecin, Olmesartan Medoxomil, DE and CDE ring analogs of camptothecin, and homologs of 1,25-dihydroxyvitamin D3.

General Description

Kinetics and mechanism of gas-phase elimination of trimethyl orthobutyrate has been examined over the temperature range of 310-369°C and pressure range of 50-130Torr.

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