Trimethyl orthobutyrate Chemical Properties

Boiling point:

145-147 °C (lit.)

Density 

0.926 g/mL at 25 °C (lit.)

refractive index 

1.402-1.404

Flash point:

50 °C

storage temp. 

Flammables area

solubility 

Chloroform, Ethyl Acetate

form 

Liquid

color 

Clear colorless to slightly yellow

Specific Gravity

0.926

BRN 

1737319

CAS DataBase Reference

43083-12-1(CAS DataBase Reference)

NIST Chemistry Reference

Trimethyl orthobutyrate(43083-12-1)

Safety Information

Hazard Codes 

Xi,F

Risk Statements 

36/38-10-36/37/38

Safety Statements 

37/39-26-16-36

RIDADR 

UN 3272

WGK Germany 

3

HazardClass 

3.2

PackingGroup 

III

HS Code 

29159000

MSDS

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Trimethyl orthobutyrate Usage And Synthesis

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

Trimethyl orthobutyrate has been used in the preparation of:

• 5-acetamido-9-O-butyroyl-3,5-dideoxy-D-glycero-2-nonulo pyranosonic acid
• 9-O-butyroyl-3,5-dideoxy-5-glycoloylamido-D-glycero-2-nonulo pyranosonic acid

Uses

Trimethyl orthobutyrate can be used for:

• Acylation at OH-9 of N-acetylneuraminic acid and N-glycoloylneuraminic acid to give the corresponding 9-O-acylated derivatives.
• Conversion of 2-amino-N-(1-H-benzimidazol-2-yl)benzamide to 2-propyl-3-benzimidazolyl-4(3H)-quinazolinone.
• Preparation of 2-propyl substituted benzimidazoles from 1,2-benzenediamines.

It can also be used in the total synthesis of dl-camptothecin, Olmesartan Medoxomil, DE and CDE ring analogs of camptothecin, and homologs of 1,25-dihydroxyvitamin D₃.

General Description

Kinetics and mechanism of gas-phase elimination of trimethyl orthobutyrate has been examined over the temperature range of 310-369°C and pressure range of 50-130Torr.

Trimethyl orthobutyrate(43083-12-1)Related Product Information

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• ORTHODICHLOROACETIC ACID TRIETHYL ESTER
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