Triethyl orthoacetate Chemical Properties

Boiling point:

142 °C (lit.)

Density 

0.885 g/mL at 25 °C (lit.)

vapor pressure 

3.4 hPa (20 °C)

RTECS 

KJ4075000

refractive index 

n20/D 1.396(lit.)

Flash point:

97 °F

storage temp. 

Store below +30°C.

solubility 

soluble in Chloroform, Ethyl Acetate

form 

Liquid

color 

Clear colorless to slightly yellow

explosive limit

0.9-7.0%(V)

Water Solubility 

SLIGHTLY SOLUBLE

Sensitive 

Moisture Sensitive

BRN 

506201

LogP

2.6 at 20℃

CAS DataBase Reference

78-39-7(CAS DataBase Reference)

NIST Chemistry Reference

Ethane, 1,1,1-triethoxy-(78-39-7)

EPA Substance Registry System

Ethane, 1,1,1-triethoxy- (78-39-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

10-36/38

Safety Statements 

26-37/39-16

RIDADR 

UN 3272 3/PG 3

WGK Germany 

1

Autoignition Temperature

455 °C

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29159080

MSDS

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Triethyl orthoacetate Usage And Synthesis

Description

Triethyl orthoacetate is the ethyl orthoester of acetic acid. It is an oily liquid with a pungent odor. Triethyl orthoacetate is used as a water scavenger and as intermediate for synthesis of pharmaceuticals. It is used in organic synthesis for the introduction of the acetate group to an alcohol and in the Johnson-Claisen rearrangement.

Reference

• J. S. Lindsey, I. C. Schreiman, H. C. Hsu, P. C. Kearney, A. M. Marguerettaz, Rothemund and Adler-Longo reactions revisited: synthesis of tetraphenylporphyrins under equilibrium conditions, The Journal of Organic Chemistry, 1987, vol. 52, pp. 827-836
• R. C. Capozza, Polymeric orthoesters housing beneficial drug for controlled release therefrom, Patent US4066747A

Chemical Properties

clear colourless liquid

Uses

Intermediate.

Uses

Triethyl orthoacetate is used as pharmaceutical and water scavenger. It is also used in organic synthesis to introduce the acetate group into an alcohol. It is involved in the Johnson-Claisen rearrangement.

Hazard

Moderate fire risk.

Flammability and Explosibility

Flammable

Triethyl orthoacetate(78-39-7)Related Product Information

• Ethyl acetate
• Triethyl phosphate
• Triethyl methanetricarboxylate
• Ethyl trifluoroacetate
• acetic acid, triethoxy-, ethyl ester
• Ethyl cyanoacetate
• Ethyl chloroacetate
• Triethyl phosphite
• Ethyl phenylacetate
• Triethyl phosphonoacetate
• Tetramethoxymethane
• Dimethyl itaconate
• Diethyl phosphite
• Trimethyl orthobutyrate
• Tripropyl orthoformate
• TRILAURIN
• Homosalate
• PROTOGRACILLIN(P)