Tetraethyl orthocarbonate Chemical Properties

Melting point:

222 °C

Boiling point:

159 °C (lit.)

Density 

0.919 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.392(lit.)

Flash point:

127 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

soluble in Chloroform, Methanol

form 

clear liquid

Specific Gravity

0.919

color 

Colorless to Almost colorless

Water Solubility 

Insoluble

Sensitive 

Moisture Sensitive

BRN 

1747401

CAS DataBase Reference

78-09-1(CAS DataBase Reference)

NIST Chemistry Reference

Ethane, 1,1',1'',1'''-[methanetetrayltetrakis(oxy)]tetrakis-(78-09-1)

EPA Substance Registry System

Ethane, 1,1',1'',1'''-[methanetetrayltetrakis(oxy)]tetrakis- (78-09-1)

Safety Information

Hazard Codes 

Xi,F

Risk Statements 

10-36/37/38

Safety Statements 

37/39-26-16-36-24/25

RIDADR 

UN 3272 3/PG 3

WGK Germany 

3

F 

21

HazardClass 

3

PackingGroup 

III

HS Code 

29209010

MSDS

• Language:English Provider:Tetraethoxymethane
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Tetraethyl orthocarbonate Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Tetraethyl Orthocarbonate is used in the synthesis of chemokine receptor-5 inhibitors against HIV-1, benzobisoxazoles and in the preparation of organic semiconductors. It is also employed in the synthesis of 2,7-dimethylene-1,4,6,9-tetraoxaspiro[4,4]nonane and in the synthesis of cross linked poly(orthocarbonate)s used as organic solvent absorbent.

Purification Methods

Likely impurities are hydrolysis products. Shake the orthocarbonate with brine (saturated NaCl, dilute with a little Et2O if amount of material is small) and dry (MgSO4). The organic layer is filtered off and evaporated, and the residue is distilled through a helices packed fractionating column with a total reflux partial take-off head. All distillations can be done at atmospheric pressure in an inert atmosphere (e.g. N2). [Roberts & McMahon Org Synth Coll Vol IV 457 1963, Connolly & Dyson J Chem Soc 828 1937, Tieckelmann & Post J Org Chem 13 266 1948, for review see Kantlehner et al. Justus Liebigs Ann Chem 507 207 1982, Beilstein 3 IV 6.]

Tetraethyl orthocarbonate(78-09-1)Related Product Information

• SILICON TETRAACETATE
• Tetraethyl orthosilicate
• Diethyl carbonate
• Diethyl pyrocarbonate
• Tetramethoxymethane
• Ethyl methyl carbonate
• Triethyl orthoacetate
• Triethyl orthoformate
• Trimethyl orthobutyrate
• PROTOGRACILLIN(P)
• Trimethyl orthopropionate
• Triethyl orthopropionate
• 1,1,1-Trimethoxy-2-methylpropane
• Sodium lauryl ether sulfate
• LAURETH-4
• MONOLAURIN
• Protoporphyrin IX
• Trimethyl orthoacetate