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Diethyl carbonate

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Diethyl carbonate Basic information

Product Name:
Diethyl carbonate
Synonyms:
  • DPD1
  • Monoclonal Anti-TGFB1 antibody produced in mouse
  • TGFB
  • Anti-TGF β1, C-Terminal antibody produced in rabbit
  • diaphyseal dysplasia 1
  • progressive
  • Diethyl carbonate >=99%, acid <10 ppm, H2O <10 ppm
  • Diethyl carbote
CAS:
105-58-8
MF:
C5H10O3
MW:
118.13
EINECS:
203-311-1
Product Categories:
  • Protecting and Derivatizing Reagents
  • Protection and Derivatization
  • Synthetic Reagents
  • Alternative Energy
  • Chemical Synthesis
  • Materials Science
  • ElectrolytesProtection and Derivatization
  • Materials Science
  • Organic Solvents
  • Building Blocks
  • Carbonyl Compounds
  • Lithium-Ion Batteries
  • Organic Building Blocks
  • Solvents
  • Pharmaceutical Intermediates
  • Organics
  • CARBONATES
  • CarbonatesMaterials Science
  • Alternative Energy
  • Carbonyl Compounds
  • Electrolytes
  • Organic Building Blocks
  • Others
  • Protecting and Derivatizing Reagents
  • Protection and Derivatization
  • Pharm intermediates
  • Pyridines ,Halogenated Heterocycles
Mol File:
105-58-8.mol
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Diethyl carbonate Chemical Properties

Melting point:
-43 °C (lit.)
Boiling point:
126-128 °C (lit.)
Density 
0.975 g/mL at 25 °C (lit.)
vapor density 
4.1 (vs air)
vapor pressure 
10 mm Hg ( 23.8 °C)
refractive index 
n20/D 1.384(lit.)
Flash point:
88 °F
storage temp. 
no restrictions.
solubility 
18.8mg/l insoluble
form 
Liquid
color 
Clear
Odor
Pleasant, etheral; mild and nonresidual.
PH
6.3 (1g/l, H2O)
explosive limit
1.4-11.0%(V)
Water Solubility 
Negligible
Sensitive 
Moisture Sensitive
Merck 
14,3780
BRN 
956591
Stability:
Stable. Flammable. Incompatible with strong acids, strong bases, reducing agents, oxidizing agents. Protect from moisture.
CAS DataBase Reference
105-58-8(CAS DataBase Reference)
NIST Chemistry Reference
Carbonic acid, diethyl ester(105-58-8)
EPA Substance Registry System
Diethyl carbonate (105-58-8)
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Safety Information

Hazard Codes 
T,Xi
Risk Statements 
23/24/25-36/37/38-10
Safety Statements 
26-36-45-16-23
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
YE1050000
21
Autoignition Temperature
445 °C
TSCA 
Yes
HS Code 
2920 90 10
HazardClass 
3
PackingGroup 
III
Hazardous Substances Data
105-58-8(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 4900 mg/kg

MSDS

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Diethyl carbonate Usage And Synthesis

Chemical Properties

colourless liquid with a mild odour

Uses

Solvent for nitrocellulose; manufacture of radio tubes; fixing rare earths to cathode elements.

Uses

Diethyl carbonate is esters, beta-enamino esters, carbamates and unsymmetrical alkyl carbonates. It is an active component of electrolytes used in lithium which is used as a solvent for cellulose ethers, nitro cellulose, natural and synthetic resin and in erythromycin intramuscular injections. It is also used in the synthesis of 3-ethyl-4-methyl-5-phenyl-3H-oxazol-2-one, phenobarbital, pyrethrum batteries.

Production Methods

Manufacturing steps: (a) reacting chlorine and carbon monoxide to produce (COCl2); (b) reacting phosgene with ethyl alcohol to make ethyl chlorocarbonate (ClCO2C2H5); (c) reacting ethyl chlorocarbonate with anhydrous ethyl alcohol to produce diethyl carbonate.

Synthesis Reference(s)

Journal of the American Chemical Society, 104, p. 1769, 1982 DOI: 10.1021/ja00370a068

General Description

A colorless liquid with a mild pleasant odor. Diethyl carbonate is slightly less dense than water and insoluble in water. Hence floats on water. Flash point 77°F. Vapors are heavier than air. When heated to high temperatures Diethyl carbonate may emit acrid smoke. Used as a solvent.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Diethyl carbonate reacts with acids to liberate heat along with ethanol and carbon dioxide. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides.

Health Hazard

High vapor concentrations can cause headache, irritation of eyes and respiratory tract, dizziness, nausea, weakness, loss of consciousness.

Chemical Reactivity

Reactivity with Water Too slow to be hazardous; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Wdly toxic by subcutaneous route. Questionable carcinogen with experimental tumorigenic and teratogenic data. A dangerous fire hazard when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also ANHYDRIDES.

Carcinogenicity

A study using male and female mice treated with 0, 50, 250, or 1000 ppm (0–140 mg/kg/day) diethyl carbonate in drinking water indicated no carcinogenic effects.

Purification Methods

Wash the ester (100mL) with an aqueous 10% Na2CO3 (20mL) solution, saturated CaCl2 (20mL), then water (30mL). After drying by standing over solid CaCl2 for 1hour (note that prolonged contact should be avoided because slow combination with CaCl2 occurs), it should be fractionally distilled. Also dry it over MgSO4 and distil it. [Beilstein 3 H 5, 3 I 4, 3 II 4, 3 III 5, 3 IV 5.]

Diethyl carbonateSupplier

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