(S)-(+)-Glycidyl Phthalimide Chemical Properties

Melting point:

102 °C

Boiling point:

347.4±15.0 °C(Predicted)

Density 

1.446±0.06 g/cm3(Predicted)

vapor pressure 

0.001-2.17Pa at 25-90.25℃

refractive index 

10 ° (C=2.2, CHCl3)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

pka

-2.24±0.20(Predicted)

form 

Solid

color 

White

InChI

InChI=1S/C11H9NO3/c13-10-8-3-1-2-4-9(8)11(14)12(10)5-7-6-15-7/h1-4,7H,5-6H2/t7-/m0/s1

InChIKey

DUILGEYLVHGSEE-ZETCQYMHSA-N

SMILES

C1(=O)C2=C(C=CC=C2)C(=O)N1C[C@H]1CO1

LogP

1.2 at 40℃

Safety Information

Hazard Codes 

Xi

Risk Statements 

41

Safety Statements 

26-39

WGK Germany 

2

HS Code 

29252900

(S)-(+)-Glycidyl Phthalimide Usage And Synthesis

Chemical Properties

White powder

Uses

(S)-(+)-Glycidyl Phthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid (L466500). It is also a key intermediate of rivaroxaban.

Synthesis

Phthalimide and (S)-1-substituent propylene oxide are used as raw materials, a reaction occurs under the action of a catalyst to generate 2-((S)-3-substituent-2-hydroxypropyl isodihydroindole-1,3-dione, and finally (S)-glycidyl phthalimide is generated by means of a ring-closure reaction.

(S)-(+)-Glycidyl Phthalimide(161596-47-0)Related Product Information

• N-(Chloromethyl)phthalimide
• 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
• Rivaroxaban Impurity 34
• 1,2-Cyclohexanedione
• (S)-(+)-Epichlorohydrin
• 4-(4-NITROPHENYL)MORPHOLIN-3-ONE
• 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one
• (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl
• 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
• Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
• 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-
• 5-Chloro-2-thiophenecarboxylic Acid
• m-(Trifluoromethyl)phenylacetic acid
• 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
• Rivaroxaban Impurity 43
• Rivaroxaban iMpurity 5
• AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-
• Rivaroxaban Impurity 38