Pazopanib-d6 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: 16 mg/ml; DMSO: 16 mg/ml

form 

A solid

Pazopanib-d6 Usage And Synthesis

Description

Pazopanib-d₆ is intended for use as an internal standard for the quantification of pazopanib by GC- or LC-MS. Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC₅₀s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay).¹ It also inhibits PDGFRα, PDGFRβ, and c-Kit (IC₅₀s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional receptor tyrosine kinases. Pazopanib inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells cocultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs.² It also inhibits proliferation of multiple myeloma cells cocultured with HUVECs. Pazopanib (30 and 100 mg/kg) reduces tumor growth, induces apoptosis, decreases angiogenesis, and increases survival in a multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.

References

1. Kumar, R., Knick, V.B., Rudolph, S.K., et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity Mol. Cancer Ther. 6(7),2012-2021(2007).
2. Podar, K., Tonon, G., Satler, M., et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma Proc. Natl. Acad. Sci. USA 103(5),19478-19483(2006).

Pazopanib-d6(1219592-01-4)Related Product Information

• 1,3-DiMethyl-6-aMino-1H-indazole
• 3-AMINO-4-METHYLBENZENESULFONAMIDE
• N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
• Pazopanib Impurity 9
• N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
• 5-Amino-2-methylbenzenesulfonamide
• 2-Ethyl-5-nitrobenzenamine ,98%
• 3-Methyl-6-nitroindazole
• 2,3-dimethyl-2H-indazol-6-amine hydrochloride
• 4(1H)-Pyrimidinone, 2-chloro- (9CI)
• 1,3-Dimethyl-6-nitro-1H-indazole
• 3-Methyl-6-nitro-2H-indazole
• 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI)
• Pazopanib
• 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE
• Pazopanib Related Compound 2
• 2-Methyl-5-nitrobenzenesulfonamide
• 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide