3-Hydroxy-1-methylpiperidine Chemical Properties

Boiling point:

76-78 °C11 mm Hg(lit.)

Density 

0.999 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.475

Flash point:

158 °F

pka

14.95±0.20(Predicted)

form 

liquid

color 

Clear, orange

Water Solubility 

Fully misicible in water.

BRN 

103017

CAS DataBase Reference

3554-74-3(CAS DataBase Reference)

NIST Chemistry Reference

3-Piperidinol, 1-methyl-(3554-74-3)

EPA Substance Registry System

3-Piperidinol, 1-methyl- (3554-74-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-6/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Hydroxy-1-methylpiperidine Usage And Synthesis

Uses

Reactant for:• ;Optimization of Novobiocin scaffold to produce antitumor agents1• ;Formation of carbamates and N-alkylimidazoles2Reactant for synthesis of:• ;Pyridine derivatives as CDK5 inhibitors3• ;Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors4• ;Amino phosphite ligands5• ;Mexiletine enantiomers by nucleophilic aromatic substitution6

Uses

Reactant for Optimization of Novobiocin scaffold to produce antitumor agents, Formation of carbamates and N-alkylimidazoles. Reactant for synthesis of Pyridine derivatives as CDK5 inhibitors Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors, Amino phosphite ligands, Mexiletine enantiomers by nucleophilic aromatic substitution.

Uses

Reactant for:

• Optimization of Novobiocin scaffold to produce antitumor agents
• Formation of carbamates and N-alkylimidazoles

• Pyridine derivatives as CDK5 inhibitors
• Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors
• Amino phosphite ligands
• Mexiletine enantiomers by nucleophilic aromatic substitution

3-Hydroxy-1-methylpiperidine(3554-74-3)Related Product Information

• 3-Hydroxypyridine
• 2,2,6,6-Tetramethyl-4-piperidinol
• CHLOROPHOSPHONAZO III
• N-Methyl-2-pyrrolidone
• Methyl acrylate
• Methylparaben
• Methyl acetate
• N-Methylpiperidine
• Acetonitrile
• Haloperidol
• Methanol
• Kresoxim-methyl
• Paraquat dichloride
• Triacetonediamine
• Basic Violet 1
• 3-Hydroxypiperidine
• Methyl
• 3-Quinuclidinyl benzilate