1-Boc-piperidine Chemical Properties

Boiling point:

130-140°C 15mm

Density 

0.964 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.454(lit.)

Flash point:

188 °F

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

pka

-1.28±0.20(Predicted)

color 

Clear colorless to pale yellow

BRN 

3604898

CAS DataBase Reference

75844-69-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,N,Xi

Risk Statements 

25-36/37/38-50

Safety Statements 

26-36-45-60-61

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

3

HazardClass 

IRRITANT, KEEP COLD

PackingGroup 

Ⅲ

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-Boc-piperidine Usage And Synthesis

Chemical Properties

Colorless liquid

Synthesis

The general procedure for the synthesis of tert-butyl piperidine-1-carboxylate from hexahydropyridine and di-tert-butyl dicarbonate is as follows: hexahydropyridine (1 mmol) was added to a solution of ethanol (1 mL) containing magnetically stirred guanidine hydrochloride (15 mol%) and di-tert-butyl dicarbonate (1.2 mmol) and the reaction was stirred to completion at 35-40 °C (reaction progress was monitored by TLC or GC). Upon completion of the reaction, the ethanol is evaporated under vacuum and the residue is washed with water to remove the catalyst or dissolved in dichloromethane (or ethyl acetate) and filtered to separate the catalyst. If an organic solvent is used for post-treatment, the product is almost pure after evaporation of the organic solvent. If excess di-tert-butyl dicarbonate is used, the product can be washed with petroleum ether or hexane to recover the residual di-tert-butyl dicarbonate. If necessary, the product can be further purified by crystallization (using hexane and dichloromethane, or ether and petroleum ether as solvents) or silica gel column chromatography (ethyl acetate-hexane (1:6) as eluent).

References

[1] Synthesis, 2006, # 16, p. 2784 - 2788
[2] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322
[3] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[4] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[5] Monatshefte fur Chemie, 2011, vol. 142, # 10, p. 1035 - 1043

1-Boc-piperidine(75844-69-8)Related Product Information

• PHENCYCLIDINE-D5 HYDROCHLORIDE
• DROPERIDOL
• 2,2,6,6-Tetramethyl-4-piperidinol
• Diphenoxylate
• Haloperidol
• 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL
• tert-Butyl piperidine-4-carboxylate
• DI-TERT-BUTYL ETHER
• N-BOC-4-PIPERIDINAMINE(4-AMINO-1-BOC-PIPERIDINE )
• (+/-)-1-BOC-PIPERIDINE-2-CARBOXYLIC ACID
• N-BOC-4-Hydroxypiperidine
• 1-Boc-4-piperidylacetic acid
• N-Boc-Nortropinone
• 2-(Boc-aminomethyl)-piperidine
• 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID CID
• 3-Aminomethyl-1-N-Boc-piperidine
• (S)-N-BOC-PIPERIDINE-2-CARBOXYLIC ACID
• SULFAMETHIZOLE