4-Amino-1-Boc-piperidine
4-Amino-1-Boc-piperidine Basic information
- Product Name:
- 4-Amino-1-Boc-piperidine
- Synonyms:
-
- 1-PIPERIDINECARBOXYLIC ACID, 4-AMINO-,1,1-DIMETHYLETHYL ESTER
- 1-N-BOC-4-AMINOPIPERIDINE
- 1-T-BUTOXYCARBONYL-4-AMINOPIPERIDINE
- 1-tert-Butoxycarbonyl-4-amino-piperidine
- 1-BOC-4-PIPERIDINAMINE
- 1-BOC-4-AMINOPIPERIDINE
- 1-BUTYLOXYCARBONYL-4-AMINO-PIPERIDINE
- 4-AMINO-1-BOC-PIPERIDINE
- CAS:
- 87120-72-7
- MF:
- C10H20N2O2
- MW:
- 200.28
- EINECS:
- 1312995-182-4
- Product Categories:
-
- Piperazine
- Pyrans, Piperidines & Piperazines
- Amines
- blocks
- Piperidines, Piperidones, Piperazines
- pharmacetical
- AMINOACID
- Amines and Anilines
- Pyrans, Piperidines &Piperazines
- API intermediates
- Piperidines
- 87120-72-7
- Mol File:
- 87120-72-7.mol
4-Amino-1-Boc-piperidine Chemical Properties
- Melting point:
- 50°C
- Boiling point:
- 80/0.037mm
- Density
- 1.041±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 10.10±0.20(Predicted)
- form
- Crystalline Powder, Crystals and/or Chunks
- color
- White to pale yellow to beige
- Water Solubility
- Insoluble in water.
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7,11H2,1-3H3
- InChIKey
- LZRDHSFPLUWYAX-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(N)CC1
- CAS DataBase Reference
- 87120-72-7(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-37/38-41-36/37/38-20/21/22-20/21/2236/37/38
- Safety Statements
- 26-36/37/39-22-222636/37/39
- RIDADR
- 3259
- WGK Germany
- 2
- F
- 10-34
- Hazard Note
- Irritant
- TSCA
- N
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 29339900
MSDS
- Language:English Provider:SigmaAldrich
4-Amino-1-Boc-piperidine Usage And Synthesis
Chemical Properties
white to light yellow crystal powder
Uses
4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.
Uses
4-Amino-1-Boc-piperidine is a potent inhibitor of the CCR5 receptor. It is an x-ray crystal structure with a hydroxide solution that inhibits the growth of cancer cells. The inhibitor binding site for 4-Amino-1-Boc-piperidine was determined to be the CCR5 receptor, which is located on the surface of hematopoietic cells. The compound has been shown to inhibit human T lymphocyte proliferation in vitro and inhibit HIV replication in infected patients. 4-Amino-1-Boc-piperidine is able to inhibit the growth of cancer cells by blocking the production of cytokines, such as interleukin 2, that are needed for cell division and growth.
Application
4-Amino-1-Boc-piperidine is a pharmaceutical intermediate is applied in the treatment of anti-tumor and other drugs. It is an important fine chemical intermediate and has a wide range of uses in the pharmaceutical industry.
4-Amino-1-Boc-piperidine Preparation Products And Raw materials
Raw materials
4-Amino-1-Boc-piperidine(87120-72-7)Related Product Information
- 1-Aminopiperidine
- 4-Aminoantipyrine
- Glycine
- 4-Dimethylaminopyridine
- DROPERIDOL
- 4,4'-Diaminodiphenylsulfone
- Haloperidol
- 1-Boc-4-Methylaminopiperidine
- 4-N-BOC-Aminopiperidine
- ALTRENOGEST
- N-BOC-3-Aminopiperidine
- DI-TERT-BUTYL ETHER
- 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE
- 1-BOC-3-PIPERIDINECARBOXALDEHYDE
- N-Boc-4-piperidinemethanol
- (+/-)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE
- 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde
- N-BOC-piperidine-4-carboxylic acid