4-Amino-1-Boc-piperidine Chemical Properties

Melting point:

50°C

Boiling point:

80/0.037mm

Density 

1.041±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

10.10±0.20(Predicted)

form 

Crystalline Powder, Crystals and/or Chunks

color 

White to pale yellow to beige

Water Solubility 

Insoluble in water.

Sensitive 

Air Sensitive

InChI

InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7,11H2,1-3H3

InChIKey

LZRDHSFPLUWYAX-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCC(N)CC1

CAS DataBase Reference

87120-72-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-37/38-41-36/37/38-20/21/22-20/21/2236/37/38

Safety Statements 

26-36/37/39-22-222636/37/39

RIDADR 

3259

WGK Germany 

2

F 

10-34

Hazard Note 

Irritant

TSCA 

N

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich

4-Amino-1-Boc-piperidine Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.

Uses

4-Amino-1-Boc-piperidine is a potent inhibitor of the CCR5 receptor. It is an x-ray crystal structure with a hydroxide solution that inhibits the growth of cancer cells. The inhibitor binding site for 4-Amino-1-Boc-piperidine was determined to be the CCR5 receptor, which is located on the surface of hematopoietic cells. The compound has been shown to inhibit human T lymphocyte proliferation in vitro and inhibit HIV replication in infected patients. 4-Amino-1-Boc-piperidine is able to inhibit the growth of cancer cells by blocking the production of cytokines, such as interleukin 2, that are needed for cell division and growth.

Application

4-Amino-1-Boc-piperidine is a pharmaceutical intermediate is applied in the treatment of anti-tumor and other drugs. It is an important fine chemical intermediate and has a wide range of uses in the pharmaceutical industry.

4-Amino-1-Boc-piperidine(87120-72-7)Related Product Information

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