H-PHE-NH2 Chemical Properties

Melting point:

93-95°C

Boiling point:

356.9±35.0 °C(Predicted)

Density 

1.143±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

pka

15.85±0.50(Predicted)

form 

Powder

color 

White

optical activity

Consistent with structure

BRN 

6270941

CAS DataBase Reference

5241-58-7(CAS DataBase Reference)

Safety Information

WGK Germany 

3

HazardClass 

IRRITANT

MSDS

• Language:English Provider:SigmaAldrich

H-PHE-NH2 Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

Protected amino acid

Definition

ChEBI: An amino acid amide derived from L-phenylalanine.

Biological Activity

L-Phenylalaninamide is a chiral selector.

Synthesis

General procedure for the synthesis of (S)-2-amino-3-phenylpropionamide from L-phenylalanine methyl ester hydrochloride: intermediate 1 (L-phenylalanine methyl ester hydrochloride) was dissolved in 20% aqueous ammonia solution and the reaction was stirred for 20 hours at room temperature. Upon completion of the reaction, 50 mL of ethyl acetate was added to the reaction mixture and three extraction operations were performed. All organic phases were combined and the solvent was removed by rotary evaporator to afford Intermediate 2 ((S)-2-amino-3-phenylpropionamide) as a white solid in 2.5 g yield, 76%.

References

[1] Helvetica Chimica Acta, 2004, vol. 87, # 5, p. 1077 - 1089
[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 30, p. 6074 - 6086
[3] Chemistry - An Asian Journal, 2011, vol. 6, # 6, p. 1321 - 1324
[4] Bulletin de la Societe Chimique de France, 1989, # 5, p. 673 - 676
[5] Patent: CN108610292, 2018, A. Location in patent: Paragraph 0041; 0051; 0052

H-PHE-NH2(5241-58-7)Related Product Information

• H-PGLU-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2 (+ XNH3)
• alpha-(Benzoylamino)-4-(benzoyloxy)-N,N-dipropylbenzenepropanamide
• N,N'-Propane-1,3-diylbis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionamide]
• 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE
• H-PHE-NH2 HCL
• 3-Aminobenzamide
• Antioxidant 1098
• H-LEU-PRO-LEU-ARG-PHE-NH2
• H-PHE-MET-ARG-D-PHE-NH2
• H-PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2
• H-PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
• H-PHE-LEU-ARG-PHE-NH2
• H-PRO-PHE-NH2 HCL
• H-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2
• H-PHE-PHE-NH2 HCL
• H-LYS-HIS-GLU-TYR-LEU-ARG-PHE-NH2
• H-PHE-MET-ARG-PHE-NH2 ACETATE SALT,H-PHE-MET-ARG-PHE-NH2,H-PHE-MET-ARG-PHE-NH2 ACOH
• H-PHE-MET-ARG-PHE-NH2