2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid
2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid Basic information
- Product Name:
- 2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid
- Synonyms:
-
- -2-(hydroxyimino)
- 2-(2-Amino-4-thiazolyl)-2-hydroxyiminoaceticacid
- 2-(2-aminothiazole-4-yl)-z-hydroxyiminoaceticacid
- 2-Amino-alpha-(hydroxyimino)-4-thiazoleaceticacid
- 2-(2-AMINOTHIAZOLE-4-YL)-2-HYDROXYIMINOACETIC ACID
- (2-AMINOTHIAZOL-4-YL)HYDROXYIMINO ACETIC ACID
- (Z)-2-HYDROXYIMINO-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID
- (Z)-2-HYDROXYIMINO-2-(2-AMINOTHIAZOLE-4-YL)ACETIC ACID
- CAS:
- 66338-96-3
- MF:
- C5H5N3O3S
- MW:
- 187.18
- Product Categories:
-
- Cephalosporins
- Mol File:
- 66338-96-3.mol
2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid Chemical Properties
- Melting point:
- 190-192°C
- Boiling point:
- 539.4±42.0 °C(Predicted)
- Density
- 1.92±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly, Heated)
- form
- Solid
- pka
- 10.37±0.70(Predicted)
- color
- Pale Beige
- CAS DataBase Reference
- 66338-96-3(CAS DataBase Reference)
2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid Usage And Synthesis
Uses
(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic Acid?can be used to synthesize cephalosporin derivatives and β-lactam antibiotics.
Synthesis
68401-22-9
66338-96-3
GENERAL METHOD: NaOH (2.4 g, 0.06 mol) was dissolved in water (100 mL) and stirred under cooling in an ice bath. To this solution was added ethyl 2-(2-aminothiazol-4-yl)-2-(trans)-hydroxyiminoacetate or ethyl 2-(2-aminothiazol-4-yl)-2-(cis)-hydroxyiminoacetate (10.76 g, 0.05 mol). The reaction mixture was stirred at 15-20°C for 2-3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residual solid was dissolved in water (100 mL), decolorized by the addition of Norit (1.0 g) and filtered. Glacial acetic acid was slowly added dropwise to the filtrate under stirring until the pH reached neutral. The resulting precipitate was collected by filtration, washed with water and finally the product was purified by two ethanol recrystallizations.
References
[1] Polyhedron, 2015, vol. 85, p. 208 - 220
2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acidSupplier
- Tel
- +86 351 7031519
- sales@RHFChem.com
- Tel
- 13817811078
- sales@jingyan-chemical.com
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Tel
- 15527768836
- 1791901229@qq.com
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid(66338-96-3)Related Product Information
- 2-Aminothiazole-4-acetic acid
- Molasses
- 2-(2-Aminothiazol-4-yl)glyoxylic acid
- Cefotaxime sodium
- Cefotaxime
- 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid
- Glycine
- Ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate
- 2-(TRITYLAMINO)-ALPHA-(METHOXYIMINO)-4-THIAZOLEACETIC ACID HYDROCHLORIDE
- (Z)-2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-methyl)ethoxyiminoacetic acid
- (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid
- (Z)-2-(5-AMINO-1,2,4-THIADIAZOL-3-YL)-2-METHOXYIMINO ACETIC ACID
- Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate
- Ethyl 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate
- 2-(2-Formamidothiazole-4-yl)-2-methoxyimino acetic acid
- (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
- 2-Aminothiazole
- (Z)-[2-(Chloroacetamido)thiazole-4-yl]methoxyiminoacetic acid