1-Methyl-L-histidine Chemical Properties

Melting point:

~240 °C (dec.) (lit.)

alpha 

-24 º (c=2% in H2O)

Boiling point:

298.47°C (rough estimate)

Density 

1.2509 (rough estimate)

refractive index 

1.5950 (estimate)

storage temp. 

2-8°C(protect from light)

solubility 

Methanol (Slightly), Water (Slightly, Sonicated)

form 

Solid

pka

1.69(at 25℃)

color 

Off-White to Pale Beige

optical activity

[α]20/D 24±1°, c = 2% in H2O

BRN 

9727

Stability:

Hygroscopic

CAS DataBase Reference

332-80-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25-22

WGK Germany 

3

HS Code 

29332900

MSDS

• Language:English Provider:SigmaAldrich

1-Methyl-L-histidine Usage And Synthesis

Chemical Properties

Beige powder

Uses

The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.

Definition

ChEBI: N(tele)-methyl-L-histidine is a L-histidine derivative in which the methyl group is at N(tele)-position. It has a role as a human metabolite. It is a L-histidine derivative and a non-proteinogenic L-alpha-amino acid. It is a tautomer of a N(tele)-methyl-L-histidine zwitterion.

1-Methyl-L-histidine(332-80-9)Related Product Information

• Methylparaben
• Kresoxim-methyl
• Thiophanate-methyl
• Bensulfuron methyl
• Methyl acrylate
• L-Histidine
• 1,3-Dimethylbarbituric acid
• L-Alanine
• Carboxymethyl cellulose
• Sodium carboxymethyl cellulose
• N,N-Dimethylformamide
• 3-METHYL-L-HISTIDINE
• Methyl
• N,N'-Bis(9-fluorenylmethyloxycarbonyl)-L-histidine
• Z-HIS(BZL)-OH
• Methyl bromide
• N-Fmoc-N'-Trityl-L-histidine pentafluorophenyl ester
• N-Boc-N'-benzyloxymethyl-L-histidine