(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid
(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Basic information
- Product Name:
- (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid
- Synonyms:
-
- (R)-(+)-MTPA,(R)-(+)-Mosher'sacid
- (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%(e.e.>99.5%)
- (+)--Methoxy--(trifluoromethyl)phenylaceticacid(Moshersacid)
- (r)-(+)-à-methoxy-à-(trifluoromethyl)phenylacetic acid
- (R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid 99% (99%ee)
- (R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid (99%ee)
- (R)-(+)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetic acid, 99%
- (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
- CAS:
- 20445-31-2
- MF:
- C10H9F3O3
- MW:
- 234.17
- EINECS:
- 243-829-5
- Product Categories:
-
- Analytical Chemistry
- e.e. / Absolute Configuration Determination (NMR)
- Enantiomer Excess & Absolute Configuration Determination
- Mol File:
- 20445-31-2.mol
(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Chemical Properties
- Melting point:
- 46-49 °C(lit.)
- Boiling point:
- 105-107 °C1 mm Hg(lit.)
- alpha
- D25 +68.5 ± 1.3° (c = 1.49 in CH3OH)
- Density
- 1.344 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.473(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Soluble in methanol (50 mg/ 1 ml).
- form
- Crystalline Low Melting Solid
- pka
- 1.47±0.10(Predicted)
- Specific Gravity
- 1.344
- color
- White
- optical activity
- [α]20/D +73±1°, c = 2% in methanol
- Sensitive
- Hygroscopic
- Merck
- 14,6280
- BRN
- 2215440
- CAS DataBase Reference
- 20445-31-2(CAS DataBase Reference)
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Usage And Synthesis
Chemical Properties
white crystalline low melting solid
Uses
(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR.
Uses
Mosher′s acid chloride is used as a dervatization agent for β-arylethylamines, enantiomeric alcohols, and enantiomeric amines. It is also a reagent used for the determination of enantiomeric purity and absolute configuration of alcohols and amines by NMR.
General Description
Mosher′s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.
Purification Methods
A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]
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(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid(20445-31-2)Related Product Information
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