4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Chemical Properties

Boiling point:

648.2±55.0 °C(Predicted)

Density 

1.342±0.06 g/cm3(Predicted)

pka

10.75±0.40(Predicted)

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Usage And Synthesis

Biological Activity

Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl(2093386-50-4)Related Product Information

• Thalidomide-O-amido-C2-NH2
• 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione
• -alkylC5-amine
• Thalidomide-NH-C6-NH2 TFA
• E3 ligase Ligand-Linker Conjugates 15
• Thalidomide-O-amido-C2-NH2
• Thalidomide-NH-PEG2-C2-NH2 hydrochloride
• Thalidomide-NH-PEG2-C2-NH2 (TFA)