4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Basic information
- Product Name:
- 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- Synonyms:
-
- 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- Thalidomide-NH-PEG2-C2-NH2
- 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
- Thalidomide-PEG2-C2-NH2
- Thalidomide-4-NH-PEG2-C2-NH2
- CAS:
- 2093416-32-9
- MF:
- C19H24N4O6
- MW:
- 404.42
- Mol File:
- 2093416-32-9.mol
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4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Usage And Synthesis
Biological Activity
Thalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References
[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneSupplier
Suzhou Highfine Biotech Co., Ltd
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Daicel Chiral Technologies (China)CO.,LTD
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4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione(2093416-32-9)Related Product Information
- Thalidomide-O-amido-C2-NH2
- 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione
- -alkylC5-amine
- Thalidomide-NH-C6-NH2 TFA
- 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
- E3 ligase Ligand-Linker Conjugates 15
- Thalidomide-O-amido-C2-NH2
- Thalidomide-NH-PEG2-C2-NH2 hydrochloride
- Thalidomide-NH-PEG2-C2-NH2 (TFA)