(R)-3-Hydroxypyrrolidine Chemical Properties

Melting point:

15°C

Boiling point:

215-216 °C (lit.)

alpha 

6.5 º (c=3.5% in MeOH)

Density 

1.078 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.488(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Viscous Liquid

pka

14.91±0.20(Predicted)

Specific Gravity

1.048

color 

Clear yellow to orange-brown

optical activity

[α]20/D +6.5°, c = 3.5 in methanol

Water Solubility 

Soluble in water and methanol.

Sensitive 

Air Sensitive & Hygroscopic

BRN 

5376132

CAS DataBase Reference

2799-21-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

F 

10-34

Hazard Note 

Irritant

HS Code 

29339900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

(R)-3-Hydroxypyrrolidine Usage And Synthesis

Chemical Properties

clear yellow to orange-brown viscous liquid

Uses

(R)-Pyrrolidin-3-ol is used in preparation of allosteric BCR-ABL bifunctional proteolysis targeting chimera compounds.

Purification Methods

The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

(R)-3-Hydroxypyrrolidine(2799-21-5)Related Product Information

• N-Vinyl-2-pyrrolidone
• N-Methyl-2-pyrrolidone
• Polyvinylpyrrolidone
• 3-Pyrrolidinol
• Povidone iodine
• Pyrrolidine
• SCOPOLAMINE N-OXIDE HYDROBROMIDE
• METHYL-2-PYRROLIDONE
• Boc-Hyp-OH
• (2S,4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid
• RETRORSINE
• BOC-HYP(BZL)-OH
• CYTOCHALASIN A
• N-Cbz-Hydroxy-L-proline
• SWAINSONINE
• cis-4-Hydroxy-D-proline
• DIHYDROCYTOCHALASIN B
• CYTOCHALASIN E