5-Bromo-2-methoxypyrimidine Chemical Properties

Melting point:

55.5-59.5 °C (lit.)

Boiling point:

259.8±32.0 °C(Predicted)

Density 

1.628±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

-0.22±0.22(Predicted)

form 

Solid

color 

White to yellow (may have pinkish tinge)

CAS DataBase Reference

14001-66-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-43

Safety Statements 

37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29333990

5-Bromo-2-methoxypyrimidine Usage And Synthesis

Chemical Properties

White solid

Synthesis

Synthesis of compound 11-3 (5-bromo-2-methoxypyrimidine): to a solution of 5-bromo-2-chloropyrimidine (11-2, 2.0 g, 10 mmol) in methanol (15 mL) was added sodium methanolate (CH3ONa, 2.16 g, 40 mmol). The reaction mixture was stirred at 70 °C overnight. Upon completion of the reaction, methanol was removed by rotary evaporator under reduced pressure. Water (10 mL) was slowly added to the residue, followed by extraction with ethyl acetate (300 mL x 3). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give 11-3 as a yellow solid (1.17 g, 60% yield).

References

[1] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 289-290
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 19, p. 5849 - 5853

5-Bromo-2-methoxypyrimidine(14001-66-2)Related Product Information

• 5-BROMO-2,4-DIMETHOXYPYRIMIDINE
• 2 , 4-BIS(BENZYLOXY)-5-BROMOPYRIMIDINE
• 2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE
• 2-BROMO-6-METHOXYPYRIMIDINE
• 5-BROMO-2-METHOXYPYRIMIDIN-4-YLAMINE
• 2-Bromo-4-methoxypyridine
• 2-Bromo-6-methoxypyrimidine
• 5-Bromopyrimidine
• 5-BROMO-2-(P-TOLYLOXY)PYRIMIDINE
• N-(4-(5-bromo-2-pyrimidinyloxy)-3-chlorophenyl)-N'-(2-nitrobenzoyl)urea
• 5-BROMO-2-(4-METHOXYPHENOXY)PYRIMIDINE
• 5-BROMO-2-(4-FLUOROPHENOXY)PYRIMIDINE
• 5-BROMO-2-(4-CHLOROPHENOXY)PYRIMIDINE
• 4-[(5-BROMOPYRIMIDIN-2-YL)OXY]BENZONITRILE
• 2-AMINO-5-BROMO-4-METHOXYPYRIMIDINE
• 4-AMINO-5-BROMO-6-METHOXYPYRIMIDINE
• 5-BROMO-2,4,6-TRIETHOXYPYRIMIDINE
• N-(((4-((5-Bromo-2-pyrimidinyl)oxy)-3-nitrophenyl)amino)carbonyl)-2-ni trobenzamide