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Capillarisin

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Capillarisin Basic information

Product Name:
Capillarisin
Synonyms:
  • CAPILLARISIN
  • Capillarisin std.
  • CAPILLARISIN(RG)
  • CAPILLARISIN hplc
  • 5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one
  • 5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one
  • 2-(4-Hydroxyphenoxy)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one
  • 5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-1-benzopyran-4-one
CAS:
56365-38-9
MF:
C16H12O7
MW:
316.26
Product Categories:
  • Flavones
Mol File:
56365-38-9.mol
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Capillarisin Chemical Properties

Melting point:
approximate 225℃ (dec.)
Boiling point:
582.6±50.0 °C(Predicted)
Density 
1.551±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
6.37±0.40(Predicted)
color 
Light yellow to yellow
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Capillarisin Usage And Synthesis

Uses

Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity[1][2][3].

Definition

ChEBI: Capillarisin is a member of coumarins.

in vivo

Capillarisin (20 and 80 mg/kg; i.p.; 1 hour) pretreatment strongly inhibits NF-κB mediated genes (iNOS, COX-2)[4].
Capillarisin significantly reduces the plasma leading nitrite production. Capillarisin markedly suppresses the adenosine 5'-triphosphate (ATP) in plasma and substance P in CFA-induced paw tissue[4].

Animal Model:ICR mice[4]
Dosage:20 and 80 mg/kg
Administration:I.p.; 1 hour
Result:Pretreatment strongly inhibited NF-κB mediated genes (iNOS, COX-2).

target

TLR | NF-kB | MAPK | STAT | TNF-α | IL Receptor | NO | PGE | AP-1 | ERK | NOS | COX | MMP(e.g.TIMP) | VEGFR | JNK | Bcl-2/Bax

References

[1] Peng G, et al. Capillarisin exerts antiasthmatic activity in neonatal rats via modulating the matrix remodeling. Pak J Pharm Sci. 2020;33(4(Supplementary)):1907-1915. PMID:33612476
[2] Komiya T, et al. Capillarisin, a Constituent from Artemisiae Capillaris Herba. Chemical and Pharmaceutical Bulletin, 1975
[3] Zhao T, Wang Q. Capillarisin protects SH-SY5Y cells against bupivacaine-induced apoptosis via ROS-mediated PI3K/PKB pathway. Life Sci. 2020;259:118279. DOI:10.1016/j.lfs.2020.118279
[4] Khan S, et al. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model. J Ethnopharmacol. 2014;152(3):478-486. DOI:10.1016/j.jep.2014.01.028

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