Capillarisin

Product Name: Capillarisin
CAS No.: 56365-38-9
Chemical Name: Capillarisin
Synonyms: Capillaris;CAPILLARISIN;CAPILLARISIN(RG);CAPILLARISIN hplc;Capillarisin std.;Capillarisin Standard;Capillarisin USP/EP/BP;5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one;5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one;5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-1-benzopyran-4-one
CBNumber: CB7693122
Molecular Formula: C16H12O7
Formula Weight: 316.26
MOL File: 56365-38-9.mol

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Capillarisin Property

Melting point:: approximate 225℃ (dec.)
Boiling point:: 582.6±50.0 °C(Predicted)
Density: 1.551±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 6.37±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0013960
Product name: CAPILLARISIN
Purity: 95.00%
Packaging: 5MG
Price: $501.42
Updated: 2021/12/16

AHH

Product number: MT-04373
Product name: Capillarisin
Purity: 98%
Packaging: 0.025g
Price: $336
Updated: 2021/12/16

Arctom

Product number: CFN90317
Product name: Capillarisin
Purity: ≥98%
Packaging: 5mg
Price: $468
Updated: 2021/12/16

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Capillarisin Chemical Properties,Usage,Production

Uses

Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity[1][2][3].

Definition

ChEBI: Capillarisin is a member of coumarins.

in vivo

Capillarisin (20 and 80 mg/kg; i.p.; 1 hour) pretreatment strongly inhibits NF-κB mediated genes (iNOS, COX-2)^[4].
Capillarisin significantly reduces the plasma leading nitrite production. Capillarisin markedly suppresses the adenosine 5'-triphosphate (ATP) in plasma and substance P in CFA-induced paw tissue^[4].

Animal Model:	ICR mice^[4]
Dosage:	20 and 80 mg/kg
Administration:	I.p.; 1 hour
Result:	Pretreatment strongly inhibited NF-κB mediated genes (iNOS, COX-2).

target

TLR | NF-kB | MAPK | STAT | TNF-α | IL Receptor | NO | PGE | AP-1 | ERK | NOS | COX | MMP(e.g.TIMP) | VEGFR | JNK | Bcl-2/Bax

References

[1] Peng G, et al. Capillarisin exerts antiasthmatic activity in neonatal rats via modulating the matrix remodeling. Pak J Pharm Sci. 2020;33(4(Supplementary)):1907-1915. PMID:33612476
[2] Komiya T, et al. Capillarisin, a Constituent from Artemisiae Capillaris Herba. Chemical and Pharmaceutical Bulletin, 1975
[3] Zhao T, Wang Q. Capillarisin protects SH-SY5Y cells against bupivacaine-induced apoptosis via ROS-mediated PI3K/PKB pathway. Life Sci. 2020;259:118279. DOI:10.1016/j.lfs.2020.118279
[4] Khan S, et al. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model. J Ethnopharmacol. 2014;152(3):478-486. DOI:10.1016/j.jep.2014.01.028

Capillarisin Preparation Products And Raw materials

Raw materials

Preparation Products

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Capillarisin Suppliers

China 57 Japan 1 United Kingdom 4 United States 7 Global 69

BOC Sciences

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Chengdu Climax Biotech Co., Ltd.

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Chengdu HuaXia Chemical Reagent Co. Ltd

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Wuxi Zhongkun Biochemical Technology Co., Ltd.

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Wuhan ChemFaces Biochemical Co., Ltd.

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EMMX Biotechnology LLC

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shandong Xiya Chemical Co., Ltd.

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Shanghai ChengShao Biological Technology Co., Ltd.

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Amadis Chemical Company Limited

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56365-38-9, CapillarisinRelated Search:

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CAPILLARISIN

Capillarisin std.

CAPILLARISIN(RG)

CAPILLARISIN hplc

5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one

5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one

2-(4-Hydroxyphenoxy)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one

5,7-Dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-1-benzopyran-4-one

Capillaris

5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-1-benzopyran-4-one

Capillarisin Standard

4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-

Capillarisin USP/EP/BP

56365-38-9

Flavones