Actarit
Actarit Basic information
- Product Name:
- Actarit
- Synonyms:
-
- 4-(acetylamino)-benzeneacetic acid
- [4-(ACETYLAMINO)PHENYL]ACETIC ACID
- (p-acetamidophenyl)-aceticaci
- (p-acetamidophenyl)aceticacid
- 4-(acetylamino)-benzeneaceticaci
- 4-n-acetylaminophenylaceticacid
- ms932
- RARECHEM AL BO 1520
- CAS:
- 18699-02-0
- MF:
- C10H11NO3
- MW:
- 193.2
- EINECS:
- 242-511-3
- Product Categories:
-
- Aromatic Phenylacetic Acids and Derivatives
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 18699-02-0.mol
Actarit Chemical Properties
- Melting point:
- 173-175°C
- Boiling point:
- 449.1±28.0 °C(Predicted)
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO, Ethanol, Methanol
- form
- Solid
- pka
- 4.34±0.10(Predicted)
- color
- White to Off-White
- Merck
- 14,133
- CAS DataBase Reference
- 18699-02-0(CAS DataBase Reference)
Safety Information
- Safety Statements
- 24/25
- RTECS
- CY1542000
- HS Code
- 29163990
- Toxicity
- LD50 in male, female mice, male, female rats (mg/kg): 1.06, 1.30, 1.95, 2.03 i.p.; 5.68, 5.48, 5.48, 6.12 s.c.; 15.3, 14.7, 14.8, 15.4 orally (Toshida)
Actarit Usage And Synthesis
Description
Actarit is an orally administered disease-modifying antirheumatic drug launched in Japan. Although its structure resembles that of non-steroidal anti-inflammatory drugs, it has no effect on experimental acute inflammation and has no analgesic or antipyretic effects. Its preventative and therapeutic effects on adjuvant arthritis are mediated via modulation of production and serum level of interleukin-2 which enhances production of suppressor T-cells to the immune system, thereby, preventing development of articular lesions.
Chemical Properties
Crystalline Solid
Originator
Nippon Shlnyaku;Mltaublshl Kasel (Japan)
Uses
Antiarthritic
Uses
Chronic rheumatoid arthritis
Definition
ChEBI: Actarit is an anilide and a member of acetamides.
brand name
Orcl; Mover
Purification Methods
Crystallise the acid from MeOH/Me2CO, aqueous EtOH or H2O. The amide has m 231o (from 50% aqueous EtOH). [Gabriel Chem Ber 15 841 1882, Cerecedo et al. J Biol Chem 42 238 1924, Tramontano et al. J Am Chem Soc 110 2282 1988, Beilstein 14 II 281.]
ActaritSupplier
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Actarit(18699-02-0)Related Product Information
- Acetaminophen
- 4-Hydroxyphenylacetic acid
- 4-Methoxyphenylacetic acid
- 2-Hydroxyphenylacetic acid
- ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
- dexindoprofen
- 7-Diethylamino-3-(4'-maleimidylphenyl)-4- methylcoumarin
- Phenylacetic acid
- Indobufen
- 4-Aminophenylacetic acid
- PKSI 527
- 7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin
- (4-[(3-METHYL-FURAN-2-CARBONYL)-AMINO]-PHENYL)-ACETIC ACID
- Actarit-d4
- Desacetyl Actarit-d4
- Actarit
- ASISCHEM D13241
- N-(3-METHYL-4-(2-OXO-2H-CHROMEN-3-YL)PHENYL)-2-(O-TOLYLOXY)ACETAMIDE