Dicyclanil Chemical Properties

Boiling point:

543.6±60.0 °C(Predicted)

Density 

1.44±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

DMSO: 38 mg/mL (199.78 mM);Ethanol: 2 mg/mL (10.51 mM)

pka

4.09±0.50(Predicted)

Water Solubility 

Water: Insoluble

BRN 

9265760

CAS DataBase Reference

112636-83-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn;N,N,Xn

Risk Statements 

20/22-51/53

Safety Statements 

36/37/39-61

RIDADR 

UN 3077

WGK Germany 

2

Dicyclanil Usage And Synthesis

Description

Dicyclanil is an insect growth regulator belonging to the group of pyrimidinamines.
Dicyclanil is a pyrimidin derivative. Dicyclanil is an insect development inhibitor very specific for the prevention of blowfly strike in sheep. It does not control any other external parasites of sheep. It is used mainly as a spray-on. It is not used in other livestock, horses or pets.

Uses

Dicyclanil is a veterinary medication for the protection against early season myiasis.

Application

Dicyclanil may be used as an analytical reference standard for the quantification of the analyte in biological samples, bovine, porcine and chicken muscle using various chromatography techniques.

Pharmacokinetics

Dicyclanil has a long lasting action which interferes with moulting and pupation in dipteran species. However, the precise mode of action of this compound on ectoparasites is not known.
A variety of in vitro and in vivo pharmacodymanic tests were performed with dicyclanil in rats, mice and guinea pigs. In vitro, dicyclanil was devoid of significant effects on the neuromuscular junction at concentrations below 3 mM. Slight antagonistic effects on smooth muscle were reported at concentration levels above 0.1 mM. Dicyclanil caused a statistically significant increase in heart rate, tidal volume and minute volume at a dose level of 100 mg/kg bw in studies on the cardiovascular and respiratory systems in the rat. In various in vivo studies, dicyclanil was devoid of significant effects on behavior at a dose level of 1 mg/kg bw in mice.

Toxicity evaluation

Dicyclanil was investigated in a series of acute toxicity studies. The acute LD50 by the oral route in the rat was 520 mg/kg bw. The acute LD50 by the dermal route was greater than 2000 mg/kg bw in the rat. An acute inhalation toxicity study also conducted in the rat showed the acute LC50 to be 3,184 mg/m3 of air. The toxic effects were dyspnoea and reduced locomotor activity.

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