Basic information Safety Supplier Related

ESCHENMOSER'S SALT

Basic information Safety Supplier Related

ESCHENMOSER'S SALT Basic information

Product Name:
ESCHENMOSER'S SALT
Synonyms:
  • ESCHENMOSER SALT
  • ESCHENMOSER'S SALT
  • N,N-DIMETHYLMETHYLENEAMMONIUM CHLORIDE
  • N,N-DIMETHYL-METHYLENEIMINIUM CHLORIDE
  • DIMETHYL(METHYLIDENE)AZANIUM BROMIDE
  • N,N-dimethylmethyleneammonium bromide
  • dimethylmethylenammonium chloride
  • N,N-DIMETHYLMETHYLENEAMMONIUM CHLORIDE, TECH., 90%
CAS:
30354-18-8
MF:
C3H8ClN
MW:
93.56
EINECS:
250-142-4
Mol File:
30354-18-8.mol
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ESCHENMOSER'S SALT Chemical Properties

Melting point:
146-148 °C(lit.)
Flash point:
180 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform (Very Slightly, Heated), DMSO (Sparingly, Heated, Sonicated)
form 
Solid
color 
White to Off-White
BRN 
505955
Stability:
Hygroscopic, Unstable in Protic Solvent
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN 1325 4.1/PG 3
WGK Germany 
3
3-10-21

MSDS

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ESCHENMOSER'S SALT Usage And Synthesis

Uses

N,N-Dimethylmethyleneiminium chloride (B?hme′s salt) is a dimethylaminomethylating agent that can be used as one of the key reagents in the following applications:

  • Electrophilic aminomethylation of aldehydes and ketones to synthesize corresponding Mannich products, also known as Mannich reaction.
  • Preparation of dihydronaphthyridinones as HIV-1 integrase inhibitors.
  • Preparation of cyanotetrahydrooxo-β-carbolines via cyclocondensation of cyanomethyl indole-2-carboxylate with ammonia.
  • Asymmetric synthesis of phalarine via stereospecific Pictet-Spengler cyclocondensation and traceless chirality transfer from L-tryptophan.
  • Synthesis of functionalized diarylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX).
  • Synthesis of (±)-phalarine with the rearrangement of an azaspiroindolenine and Gassman oxindole preparation as key steps.

ESCHENMOSER'S SALTSupplier

Energy Chemical
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