ESCHENMOSER'S SALT Chemical Properties

Melting point:

146-148 °C(lit.)

Flash point:

180 °F

storage temp. 

Store below +30°C.

solubility 

Chloroform (Very Slightly, Heated), DMSO (Sparingly, Heated, Sonicated)

form 

Solid

color 

White to Off-White

BRN 

505955

Stability:

Hygroscopic, Unstable in Protic Solvent

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

UN 1325 4.1/PG 3

WGK Germany 

3

F 

3-10-21

MSDS

• Language:English Provider:SigmaAldrich

ESCHENMOSER'S SALT Usage And Synthesis

Uses

N,N-Dimethylmethyleneiminium chloride (B?hme′s salt) is a dimethylaminomethylating agent that can be used as one of the key reagents in the following applications:

• Electrophilic aminomethylation of aldehydes and ketones to synthesize corresponding Mannich products, also known as Mannich reaction.
• Preparation of dihydronaphthyridinones as HIV-1 integrase inhibitors.
• Preparation of cyanotetrahydrooxo-β-carbolines via cyclocondensation of cyanomethyl indole-2-carboxylate with ammonia.
• Asymmetric synthesis of phalarine via stereospecific Pictet-Spengler cyclocondensation and traceless chirality transfer from L-tryptophan.
• Synthesis of functionalized diarylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX).
• Synthesis of (±)-phalarine with the rearrangement of an azaspiroindolenine and Gassman oxindole preparation as key steps.

ESCHENMOSER'S SALT(30354-18-8)Related Product Information

• ETHYL VIOLET
• Toluidine Blue O
• Fast Green FCF
• PYRONIN Y
• Azure B
• Basic Blue 7
• RHODANILE BLUE
• NILE BLUE CHLORIDE
• Basic Blue 26
• ALCIAN BLUE 8GX
• (Dichloromethylene)dimethylammonium chloride
• N,N-DiMethylMethyleneaMMoniuM Iodide
• CI 45010
• Basic Blue 11
• CRYSTAL VIOLET
• Rhodamine B
• (Chloromethylene)dimethyliminium chloride
• METHYL GREEN