Aclatonium napadisilate Chemical Properties

Melting point:

189-191°

solubility 

DMSO (Slightly), Water (Slightly)

form 

Solid

color 

Crystals

Stability:

Hygroscopic

Safety Information

Toxicity

LD50 in mice: 15 g/kg orally, 826 mg/kg s.c. (Miura); in dogs: >10 g/kg orally (Takai)

Aclatonium napadisilate Usage And Synthesis

Originator

Abovis ,Toyama ,Japan ,1981

Uses

Aclatonium Napadisilate is a useful bioactive therapeutic agent for autoimmune diseases. A cholinergic agonist.

Manufacturing Process

5.2 g of bis(choline)-naphthalene-1,5-disulfonate was suspended in 30 ml of acetonitrile, and 10 g of lactic acid anhydride diacetate was added thereto. This mixture was refluxed for 3 hours. The resulting reaction mixture was allowed to stand at room temperature while cooling to precipitate the desired product crystals, which were collected by filtration. 5.5 g (76% yield) of the desired product having a melting point of 189°C to 191°C were obtained.

Therapeutic Function

Cholinergic

Safety Profile

Poison by intravenous route.Moderately toxic by subcutaneous route. An experimentalteratogen. Other experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx andSOx. A cholinergic agent.

Aclatonium napadisilate(55077-30-0)Related Product Information

• Ammonium sulfamate
• Ethyl 2,4-dioxovalerate
• Cisatracurium besylate
• ISOXADIFEN-ETHYL
• Acetoxyacetic acid
• Naphthalene-2-sulfonic acid
• Ethyl acrylate
• Sodium triacetoxyborohydride
• Ethylparaben
• acetic acid, triethoxy-, ethyl ester
• Diacerein
• Ethyl propiolate
• Ethyl acetate
• Ethyl cyanoacetate
• Ethanol
• Trimethylamine
• Silicon tetraacetate
• Trinexapac-ethyl