Ampalex
Ampalex Basic information
- Product Name:
- Ampalex
- Synonyms:
-
- CX516; BDP 12; AMPAKINE CX516
- BDP-12(Ampalex)
- ABT-224,PIPERIDINE, 1-(6-QUINOXALINYLCARBONYL)-
- 1-(QUINOXALIN-6-YLCARBONYL)PIPERIDINE
- Ampalex
- Piperidin-1-yl-quinoxalin-6-ylmethanone
- Methanone, 1-piperidinyl-6-quinoxalinyl-
- 1-(6-Quinoxalinylcarbonyl)piperidine
- CAS:
- 154235-83-3
- MF:
- C14H15N3O
- MW:
- 241.29
- EINECS:
- 200-256-5
- Product Categories:
-
- Inhibitors
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API intermediates
- Mol File:
- 154235-83-3.mol
More
Less
Ampalex Chemical Properties
- Melting point:
- 88-90°C
- Boiling point:
- 433.1±25.0 °C(Predicted)
- Density
- 1.236±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol
- pka
- -0.14±0.30(Predicted)
- form
- powder
- color
- white to light brown
- Water Solubility
- H2O: 5mg/mL, clear
More
Less
Ampalex Usage And Synthesis
Chemical Properties
Tan Solid
Uses
Ampalex is a AMPA modulator that may exhibit therapeutic properties for treating Alzheimer''s disease, schizophrenia, and mild cognitive impairment (MCI) (1,2,3,4).
Uses
It is one of a series of AMPA modulators
Definition
ChEBI: CX-516 is a N-acylpiperidine.
Biochem/physiol Actions
CX516 is a positive allosteric modulator at AMPA receptor that inhibits the deactivation of AMPA receptors. CX-516 is a nootropic and ampakine agent.
in vivo
The specific extradimensional deficits produced by sub-chronic or early postnatal postnatal phencyclidine treatment were significantly attenuated by CX516 (10, and 20 mg/kg, s.c.)[1].
| Animal Model: | Male Lister Hooded rats (56-63 postnatal day)[1] |
| Dosage: | 5, 10, 20, and 40 mg/kg |
| Administration: | Subcutaneously |
| Result: | Two doses (10 and 20 mg/kg) were highly significant in improving the extradimensional shift deficit induced by either treatment regimes. Two doses (5 and 40 mg/kg) was ineffective at reversing the extradimensional impairment induced by the sub-chronic postnatal phencyclidine treatment regime. |
AmpalexSupplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
BeiJing Hwrk Chemicals Limted
- Tel
- 0757-86329057 18934348241
- sales4.gd@hwrkchemical.com
Capot Chemical Co., Ltd
- Tel
- +86 (0) 571 85 58 67 18