Tetraethylene glycol p-toluenesulfonate Chemical Properties

Boiling point:

492.5±40.0 °C(Predicted)

Density 

1.202 g/mL at 25 °C

refractive index 

n20/D1.507

Flash point:

>110℃

storage temp. 

2-8°C

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

Oil

pka

14.36±0.10(Predicted)

color 

Colourless

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

25-34-36

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2927 8(6.1) / PGII

WGK Germany 

3

Tetraethylene glycol p-toluenesulfonate Usage And Synthesis

Description

PEG5-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

Preparation

Synthesis of tetraethylene glycol tosylate. To a solution of tetraethylene glycol (2.22 g, 11.4 mmol, 3.8 equiv) in THF at 0 °C was added 2.5 M NaOH (2 mL, 5.0 mmol, 1.7 equiv) and stirred for 30 min. Tosyl chloride (565.3 mg, 3.0 mmol, 1 equiv) was added in small portions and the mixture stirred for 5 h. The solvent was removed under reduced pressure, and the residue was taken up in CH2Cl2 (15 mL) and washed with water (3 × 10 mL). The aqueous wash was further extracted with CH2Cl2 (3 × 10 mL) and the combined organic fractions were washed with brine and dried over anhydrous Na2SO4. The dried solution was filtered and the filtrate was concentrated under reduced pressure to give 900.8 mg of a pale yellow oil (87%). The product was sufficiently pure to be used without further purification.

Tetraethylene glycol p-toluenesulfonate(77544-60-6)Related Product Information

• Hydroxy-PEG4-C2-PFP ester
• Hydroxy-PEG7-C2-PFP ester
• 1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE
• PEG6-Tos
• TETRAETHYLENE GLYCOL DI-P-TOSYLATE
• m-PEG5-Tos
• 2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate
• TRI(ETHYLENE GLYCOL) MONOMETHYL ETHER TOSYLATE
• BroMoMethyl -phosphonic acid diethyl ester
• Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate)
• Hydroxy-PEG5-C2-PFP ester
• PEG13-Tos
• PEG7-Tos
• Hydroxy-PEG3-PFP ester
• 2-(4-Methylphenyl)sulfonyloxyethanol
• Tos-PEG10-OH
• Hydroxy-PEG1-C2-PFP ester
• PEG8-Tos