2,3-Dimethoxybenzylamine Chemical Properties

Melting point:

229-230 °C(Solv: N,N-dimethylformamide (68-12-2))

Boiling point:

137 °C/11 mmHg (lit.)

Density 

1.13 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.54(lit.)

Flash point:

>230 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

9.12±0.10(Predicted)

form 

Liquid

color 

Clear colorless to pale yellow

CAS DataBase Reference

4393-09-3(CAS DataBase Reference)

NIST Chemistry Reference

Benzenemethanamine, 2,3-dimethoxy-(4393-09-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

RIDADR 

2735

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

III

HS Code 

29222900

MSDS

• Language:English Provider:SigmaAldrich

2,3-Dimethoxybenzylamine Usage And Synthesis

Chemical Properties

Colorless to light yellowliqui

Uses

2,3-Dimethoxybenzylamine was used in the synthesis of di-,tri- and tetrapeptide linked dicatechol derivatives and 1-aryl-2,3-dihydro-1H-isoindoles (isoindolines).

Synthesis

Add 14.0g of anhydrous zinc chloride, 11.0g of potassium borohydride and 150ml of tetrahydrofuran into a 500ml round bottom flask, protected by nitrogen, stirred at room temperature for 2.5 hours, add 60ml of toluene and 13.0g of 2,3-dimethoxybenzoic acid amine, evaporate part of the solvent with heat and react at 100 for 3.5 hours, after cooling, pour into 150mL of 10% hydrochloric acid, then dropwise add 10% potassium hydroxide solution to pH 11, filtered, the filtrate was extracted with ether (20 ml), the extracts were combined, dried with anhydrous sodium sulfate, evaporated off the ether, distilled under reduced pressure, and 6.72 g of the fractions at 151~152.5 C/13 mmHg were collected, 71.9% yield of 2,3-dimethoxybenzylamine.

2,3-Dimethoxybenzylamine(4393-09-3)Related Product Information

• 1,1-Dimethoxyethane
• 4-Fluorobenzylamine
• Phenoxybenzamine hydrochloride
• Trimethoprim
• Dimethyldimethoxysilane
• 4-Methoxybenzylamine
• Diphenyldimethoxysilane
• 2,3-DIMETHOXYBENZAMIDE
• (+)-CORYPALMINE
• NOSCAPINE HYDROCHLORIDE
• Narcotine
• Corydaline
• BERBAMINE
• 2,6-DIMETHOXYBENZYLAMINE,2,6-Dimethoxybenzylamine 95%
• 3,5-DIMETHOXYBENZYLAMINE
• 3,4-DIMETHOXYBENZYLAMINE,3,4-Dimethoxybenzylamine 96%,3,4-Dimethoxybenzylamine ,98%
• cularine
• HYDROCOTARNINE HYDROBROMIDE