Euparin
Euparin Basic information
- Product Name:
- Euparin
- Synonyms:
-
- 5-Acetyl-2-isopropenylbenzofuran-6-ol
- 5-Acetyl-6-hydroxy-2-isopropenylbenzofuran
- Methyl(2-isopropenyl-6-hydroxybenzofuran-5-yl) ketone
- EUPARIN(P)
- Euparine
- Euparin
- Ethanone, 1-[6-hydroxy-2-(1-methylethenyl)-5-benzofuranyl]-
- 1-(6-hydroxy-2-prop-1-en-2-yl-1-benzofuran-5-yl)ethanone
- CAS:
- 532-48-9
- MF:
- C13H12O3
- MW:
- 216.23
- Mol File:
- 532-48-9.mol
Euparin Chemical Properties
- Melting point:
- 152-153℃
- Boiling point:
- 296.65°C (rough estimate)
- Density
- 1.2003 (rough estimate)
- refractive index
- 1.4740 (estimate)
- storage temp.
- Store at -20°C, sealed storage, away from moisture and light
- form
- Solid
- pka
- 9.33±0.40(Predicted)
- color
- Light yellow to yellow
- LogP
- 3.450 (est)
Euparin Usage And Synthesis
Uses
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects[1][2].
Definition
ChEBI: A natural product found in Eupatorium cannabinum subspecies asiaticum.
in vivo
Euparin (8, 16 and 32 mg/kg) reduces depression-like behavior in Chronic Unpredictable Mild Stress (CUMS) model of mice. All doses of Euparin are found to increase the contents of monoamine neurotransmitter and decrease monoamine oxidase and reactive oxygen species (ROS) levels in brain of depression mice. Euparin restores CUMS-induced decrease of Spermidine/Spermine N1-Acetyltransferase 1 (SAT1), N-methyl-D-aspartate receptor subtype 2B (NMDAR2B) and brain derived neurotrophic factor (BDNF) expression[2].
References
[1] aría Florencia Visintini Jaime, et al. Antipoliovirus Activity of the Organic Extract of Eupatorium buniifolium: Isolation of Euparin as an Active Compound. Evid Based Complement Alternat Med. 2013;2013:402364. DOI:10.1155/2013/402364
[2] Xu-Meng Han, et al. Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and SAT1/NMDAR2B/BDNF Signal Pathway. Biol Pharm Bull. 2020 Oct 1;43(10):1490-1500. DOI:10.1248/bpb.b20-00093
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